Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 19/20 | 0.56 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149388 | 0.98 | ENPP2 (0.55) | ENPP2ATXN2POLBMAPTNPSR1 | |
| Hydrochloric Acid SCHEMBL28168579 | 0.97 | ENPP2 (0.54) | ENPP2ATXN2POLBMAPTNPSR1 | |
| SCHEMBL25208544 | 0.86 | ENPP2 (0.53) | ENPP2ATXN2 | |
| SCHEMBL6236015 | 0.86 | MEN1 (0.62) | ENPP2ATXN2NPSR1 | |
| SCHEMBL171688 | 0.86 | ENPP2 (0.53) | ENPP2ATXN2KCNH2 | |
| SCHEMBL28032076 | 0.85 | ENPP2 (0.54) | ENPP2ATXN2 | |
| SCHEMBL543130 | 0.85 | ENPP2 (0.55) | ENPP2ATXN2POLBKCNH2 | |
| Hydrochloric Acid SCHEMBL34463580 | 0.84 | ENPP2 (0.52) | ENPP2ATXN2KCNH2 | |
| SCHEMBL25244326 | 0.84 | ENPP2 (0.61) | ENPP2KCNH2 | |
| SCHEMBL10102919 | 0.83 | ENPP2 (0.60) | ENPP2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | claimed |
| WO-2022003557-A1 | NOVEL INHIBITORS OF AUTOTAXIN | CADILA HEALTHCARE LIMITED (IN) | 2022-01-06 | — | — | WO | disclosed |