Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171512 | 1.00 | RET (0.38) | RETTDP2KDM4EMAPTNPSR1 | |
| SCHEMBL5873886 | 0.84 | CCNT1 (0.35) | RETCCNT1CDK9NPY5RLCLAT1 | |
| SCHEMBL5873883 | 0.84 | CCNT1 (0.35) | RETCCNT1CDK9NPY5RLCLAT1 | |
| SCHEMBL5421335 | 0.81 | RET (0.42) | RETTDP2NPSR1CDK9CSF1R | |
| SCHEMBL5873797 | 0.81 | RET (0.42) | RETTDP2NPSR1CDK9CSF1R | |
| SCHEMBL5421327 | 0.81 | RET (0.42) | RETTDP2NPSR1CDK9CSF1R | |
| SCHEMBL7703527 | 0.79 | RET (0.46) | RETTDP2MAPTCDK9CSF1R | |
| SCHEMBL5432746 | 0.79 | RET (0.46) | RETTDP2CDK9CSF1RFGFR1 | |
| SCHEMBL5432741 | 0.79 | RET (0.46) | RETTDP2CDK9CSF1RFGFR1 | |
| SCHEMBL7703531 | 0.79 | RET (0.46) | RETTDP2MAPTCDK9CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | claimed |
| US-20070213403-A1 | TAMOXIFEN RESPONSE IN PRE-AND POSTMENOPAUSAL BREAST CANCER PATIENTS | FORSKARPATENT I SYD AB (SE) | 2007-09-13 | — | — | US | disclosed |