Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.53 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677057 | 0.88 | KDM4E (0.52) | ENPP2ATXN2HTR6TACR1HTR2C | |
| SCHEMBL16825208 | 0.86 | ENPP2 (0.53) | ENPP2ATXN2MMP1MMP2MMP9 | |
| SCHEMBL171688 | 0.86 | ENPP2 (0.53) | ENPP2ATXN2 | |
| Hydrochloric Acid SCHEMBL34463580 | 0.85 | ENPP2 (0.52) | ENPP2ATXN2 | |
| SCHEMBL4682528 | 0.84 | HTR2C (0.47) | ENPP2ATXN2HTR6HTR2CHTR2A | |
| SCHEMBL148277 | 0.83 | SCN5A (0.50) | ENPP2ATXN2MMP1MMP2MMP9 | |
| Hydrochloric Acid SCHEMBL16616349 | 0.83 | ENPP2 (0.61) | ENPP2ATXN2MMP1MMP2MMP9 | |
| SCHEMBL3778880 | 0.83 | MEN1 (0.66) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL17272 | 0.83 | MEN1 (0.66) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL3889285 | 0.83 | MEN1 (0.66) | HTR2CHTR2AHTR2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | claimed |
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | disclosed |