SCHEMBL543021

SCHEMBL543021

COc1ccc2c(c[n+](C)c3c4ccc5c(c4ccc23)OCO5)c1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BAD Q92934 7/20 0.56
ALDH1A1 P00352 6/20 0.56
MAPT P10636 6/20 0.56
HPGD P15428 6/20 0.56
SMN1; SMN2 Q16637 6/20 0.56
MAPK1 P28482 5/20 0.56
KMT2A Q03164 5/20 0.56
MEN1 O00255 4/20 0.56
LMNA P02545 4/20 0.56
KDM4E B2RXH2 4/20 0.56
BCHE P06276 3/20 0.56
ACHE P22303 3/20 0.56
TP53 P04637 3/20 0.56
CYP3A4 P08684 3/20 0.56
ALOX15 P16050 3/20 0.56
ALOX12 P18054 3/20 0.56
HSD17B10 Q99714 3/20 0.56
RGS17 Q9UGC6 2/20 0.56
NPC1 O15118 2/20 0.56
USP2 O75604 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29670768 0.90 ALDH1A1 (0.54) BADALDH1A1MAPTHPGDSMN1; SMN2
Fagaridine SCHEMBL29369428 0.83 ALDH1A1 (0.77) BADALDH1A1MAPTHPGDSMN1; SMN2
Fagaridine SCHEMBL108986 0.83 ALDH1A1 (0.77) BADALDH1A1MAPTHPGDSMN1; SMN2
Fagaridine SCHEMBL6961260 0.82 ALDH1A1 (0.78) BADALDH1A1MAPTHPGDSMN1; SMN2
Fagaridine SCHEMBL9547964 0.82 ALDH1A1 (0.76) BADALDH1A1MAPTHPGDSMN1; SMN2
Fagaridine SCHEMBL8711761 0.82 ALDH1A1 (0.76) BADALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL543020 0.81 ALDH1A1 (0.42) BADALDH1A1MAPTHPGDSMN1; SMN2
Fagaridine SCHEMBL31756471 0.80 ALDH1A1 (0.65) BADALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL10132560 0.80 BAD (0.76) BADALDH1A1MAPTHPGDSMN1; SMN2
Fagaridine SCHEMBL8310818 0.78 ALDH1A1 (0.69) BADALDH1A1MAPTHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2900241-A2 NOVEL COMPOUNDS THAT ARE ERK INHIBITORS Merck Sharp & Dohme Corp. (US) 2015-08-05 EP disclosed
EP-2688872-A1 AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES Merck Sharp & Dohme Corp. (US) 2014-01-29 EP disclosed
WO-2012129258-A1 AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES MERCK SHARP & DOHME CORP. (US) 2012-09-27 WO disclosed
EP-2414330-A2 PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS Merck Patent GmbH (DE) 2012-02-08 EP disclosed
EP-2310384-A1 INHIBITORS OF JANUS KINASES Merck Sharp & Dohme Corp. (US) 2011-04-20 EP disclosed
WO-2010115491-A2 PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS MERCK PATENT GMBH (DE) 2010-10-14 WO disclosed
WO-2010005841-A1 INHIBITORS OF JANUS KINASES MERCK & CO., INC. (US) 2010-01-14 WO disclosed
EP-1656133-A4 MITOTIC KINESIN INHIBITORS MERCK & CO INC (US) 2008-10-29 EP disclosed
EP-1874769-A1 NOVEL AZA- HETEROCYCLES SERVING AS KINASE INHIBITORS Merck Patent GmbH (DE) 2008-01-09 EP disclosed
EP-1696927-A4 MITOTIC KINESIN INHIBITORS MERCK & CO INC (US) 2007-10-31 EP disclosed
WO-2006023440-A2 MITOTIC KINESIN INHIBITORS MERCK & CO., INC. (US) 2006-03-02 WO disclosed
EP-1629284-A2 METHODS FOR IDENTIFYING MODULATORS OF KINESIN ACTIVITY Rosetta Inpharmatics LLC. (US) 2006-03-01 EP disclosed
WO-2006017214-A2 INHIBITORS OF HISTONE DEACETYLASE MERCK & CO., INC. (US) 2006-02-16 WO disclosed
WO-2005065183-A2 MITOTIC KINESIN INHIBITORS MERCK & CO., INC. (US) 2005-07-21 WO disclosed
EP-1534268-A2 TYROSINE KINASE INHIBITORS Merck & Co., Inc. (US) 2005-06-01 EP disclosed
WO-2005019192-A1 UREA DERIVATIVES AND THEIR USE AS TYROSINKINASE INHIBITORS MERCK PATENT GMBH (DE) 2005-03-03 WO disclosed
WO-2005019216-A1 AMINOBENZIMIDAZOLE DERIVATIVES MERCK PATENT GMBH (DE) 2005-03-03 WO disclosed
WO-2005017190-A2 MITOTIC KINESIN INHIBITORS MERCK & CO., INC. (US) 2005-02-24 WO disclosed
WO-2004109290-A2 METHODS FOR IDENTIFYING MODULATORS OF KINESIN ACTIVITY ROSETTA INPHARMATICS LLC (US) 2004-12-16 WO disclosed
WO-2004014300-A2 TYROSINE KINASE INHIBITORS MERCK & CO., INC. (US) 2004-02-19 WO disclosed