Sugi Predict

Sugi Predict / Compounds / SCHEMBL543113

SCHEMBL543113

SCHEMBL543113

Cc1ccc(COc2cc[c]cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 6/20 0.54
▸ PARP10 Q53GL7 1/20 0.53
▸ NPC1 O15118 3/20 0.51
▸ RAB9A P51151 3/20 0.51
▸ CASP3 P42574 1/20 0.51
▸ SMN1; SMN2 Q16637 1/20 0.51
▸ SENP8 Q96LD8 1/20 0.51
▸ SENP7 Q9BQF6 1/20 0.51
▸ SENP6 Q9GZR1 1/20 0.51
▸ ALDH1A1 P00352 1/20 0.50
▸ MAPT P10636 1/20 0.50
▸ MAPK1 P28482 1/20 0.50
▸ HRH3 Q9Y5N1 1/20 0.50
▸ AGXT P21549 2/20 0.47
▸ MAOA P21397 2/20 0.46
▸ APP P05067 1/20 0.45
▸ LMNA P02545 1/20 0.44
▸ HPGD P15428 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6654510 0.92 MAOB (0.54) MAOBPARP10NPC1RAB9ACASP3
SCHEMBL8929713 0.85 MAOB (0.69) MAOBPARP10NPC1RAB9ACASP3
SCHEMBL891195 0.85 MAOB (0.69) MAOBPARP10NPC1RAB9ACASP3
SCHEMBL8930213 0.85 MAOB (0.69) MAOBPARP10NPC1RAB9ACASP3
SCHEMBL762195 0.85 MAOB (0.69) MAOBPARP10NPC1RAB9ACASP3
SCHEMBL864988 0.82 APP (0.65) MAOBNPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL6741410 0.82 PARP10 (0.54) MAOBPARP10SMN1; SMN2MAOA
SCHEMBL6544765 0.82 APP (0.60) PARP10CASP3SENP8SENP7SENP6
SCHEMBL10840203 0.81 KCNH2 (0.51) MAOBNPC1RAB9ASMN1; SMN2HRH3
SCHEMBL696444 0.80 MAOB (0.61) MAOBNPC1RAB9AAGXTMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019170046-A1 GLYCOPEPTIDE COMPOUNDS HAVING ACTIVITY OF RESISTING DRUG-RESISTANT BACTERIA, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 上海来益生物药物研究开发中心有限责任公司 2019-09-12 — — WO claimed
US-11931412-B2 JAK1 inhibitors and uses thereof WASHINGTON UNIVERSITY (US) 2024-03-19 — — US disclosed
US-20210338812-A1 JAK1 INHIBITORS AND USES THEREOF WASHINGTON UNIVERSITY (US) 2021-11-04 — — US disclosed
CN-108409837-B Glycopeptide compound with anti-drug resistance bacterial activity, preparation method and application thereof 上海来益生物药物研究开发中心有限责任公司 2021-09-24 — — CN disclosed
US-10973913-B2 JAK inhibitors and uses thereof WASHINGTON UNIVERSITY (US) 2021-04-13 — — US disclosed
US-20200282051-A1 JAK INHIBITORS AND USES THEREOF WASHINGTON UNIVERSITY (US) 2020-09-10 — — US disclosed
CN-107406590-B Resin, photosensitive resin composition, and electronic component and display device using the same 东丽株式会社 2020-08-04 — — CN disclosed
WO-2019170046-A1 GLYCOPEPTIDE COMPOUNDS HAVING ACTIVITY OF RESISTING DRUG-RESISTANT BACTERIA, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 上海来益生物药物研究开发中心有限责任公司 2019-09-12 — — WO disclosed
WO-2017143014-A1 JAK INHIBITORS AND USES THEREOF KIM BRIAN (US) 2017-08-24 — — WO disclosed
US-9650362-B2 Inhibitors PROBIODRUG AG (DE) 2017-05-16 — — US disclosed
EP-0524419-B1 Heat-sensitive recording materials and phenol compounds MITSUI TOATSU CHEMICALS (JP) 1995-09-06 — — EP disclosed
EP-0629217-A4 RIGID-ROD POLYMERS. MAXDEM INC (US) 1995-03-29 — — EP disclosed
US-5391806-A A storage stable chromogens as color-developing agent or stabilizers MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1995-02-21 — — US disclosed
EP-0629217-A1 RIGID-ROD POLYMERS MAXDEM INCORPORATED (US) 1994-12-21 — — EP disclosed
US-5306688-A Color-forming, electron donating compound and electron accepting compound; storage stability of uncolored portion MITSUI TOATSU CHEMICALS, INC. (JP) 1994-04-26 — — US disclosed
US-5270281-A Chromogenic compound MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1993-12-14 — — US disclosed
WO-1993018076-A1 RIGID-ROD POLYMERS MAXDEM INCORPORATED (US) 1993-09-16 — — WO disclosed
EP-0534257-A1 Salicylic acid derivatives, the process for preparing the same and the heat-sensitive recording materials comprising thereof MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-03-31 — — EP disclosed
EP-0524419-A1 Heat-sensitive recording materials and phenol compounds MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-01-27 — — EP disclosed
US-4578107-A Herbicidal imidazolidine-2-one derivatives OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1986-03-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210338812-A1 JAK1 INHIBITORS AND USES THEREOF JAK1, JAK2, JAK3 MAOB 3202/4885PARP10 2182/4885NPC1 1154/4885
US-10973913-B2 JAK inhibitors and uses thereof JAK2, JAK1, JAK3 MAOB 1829/4885PARP10 2675/4885NPC1 600/4885
US-11931412-B2 JAK1 inhibitors and uses thereof JAK1, JAK3, JAK2 MAOB 2462/4885PARP10 1829/4885NPC1 1585/4885
US-20200282051-A1 JAK INHIBITORS AND USES THEREOF JAK2, JAK1, JAK3 MAOB 1829/4885PARP10 2675/4885NPC1 600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.