Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 19/20 | 0.91 |
| ▸ | ICAM1 | P05362 | 19/20 | 0.91 |
| ▸ | ITGAL | P20701 | 19/20 | 0.91 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5428800 | 0.95 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL5424355 | 0.87 | ITGB2 (0.85) | ITGB2ICAM1ITGAL | |
| SCHEMBL5423136 | 0.83 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL5421572 | 0.81 | ITGB2 (0.90) | ITGB2ICAM1ITGAL | |
| SCHEMBL5423081 | 0.78 | ITGB2 (0.67) | ITGB2ICAM1ITGAL | |
| SCHEMBL5419733 | 0.73 | ITGB2 (0.78) | ITGB2ICAM1ITGAL | |
| SCHEMBL12297600 | 0.72 | ITGB2 (0.61) | ITGB2ICAM1ITGAL | |
| SCHEMBL5431078 | 0.72 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL12297597 | 0.70 | ITGB2 (0.59) | ITGB2ICAM1ITGALDRD2ADRA1A | |
| SCHEMBL5420769 | 0.69 | ITGB2 (0.69) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066585-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | WANG GARY T | 2007-03-22 | — | — | US | disclosed |
| US-20070066585-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | WANG GARY T | 2007-03-22 | — | — | US | disclosed |
| US-20070066585-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | WANG GARY T | 2007-03-22 | — | — | US | disclosed |
| US-7129247-B2 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents | ABBOTT LABORATORIES (US) | 2006-10-31 | — | — | US | disclosed |
| US-20050014746-A1 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-supressive agents | ICOS CORPORATION | 2005-01-20 | — | — | US | disclosed |
| US-6787542-B2 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents | ICOS CORPORATION | 2004-09-07 | — | — | US | disclosed |
| EP-1294704-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | ABBOTT LABORATORIES (US) | 2003-03-26 | — | — | EP | disclosed |
| US-20020132807-A1 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents | ICOS CORPORATION | 2002-09-19 | — | — | US | disclosed |
| WO-2002002539-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | ABBOTT LABORATORIES (US) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020132807-A1 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents | VCAM1, ICAM1, CD47 | ITGB2 70/4885ICAM1 2/4885ITGAL 97/4885 |
| US-20050014746-A1 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-supressive agents | ICAM1, VCAM1, CD47 | ITGB2 45/4885ICAM1 1/4885ITGAL 80/4885 |
| US-20070066585-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | VCAM1, ICAM1, CD47 | ITGB2 70/4885ICAM1 2/4885ITGAL 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.