Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.32 |
| ▸ | TTR | P02766 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5434596 | 1.00 | JAK2 (0.34) | JAK2CHEK1HSD17B1HSD17B2TTR | |
| SCHEMBL5434301 | 0.91 | JAK2 (0.35) | JAK2CHEK1HSD17B1HSD17B2KDM4E | |
| SCHEMBL14505513 | 0.91 | JAK2 (0.35) | JAK2CHEK1HSD17B1HSD17B2KDM4E | |
| SCHEMBL5434298 | 0.91 | JAK2 (0.35) | JAK2CHEK1HSD17B1HSD17B2KDM4E | |
| SCHEMBL5434702 | 0.88 | HDAC1 (0.34) | JAK2CHEK1KDM4EMEN1KMT2A | |
| SCHEMBL5434704 | 0.88 | HDAC1 (0.34) | JAK2CHEK1KDM4EMEN1KMT2A | |
| SCHEMBL5727937 | 0.88 | ACKR3 (0.32) | ACKR3RIPK1OPRM1HDAC1HDAC2 | |
| SCHEMBL5438170 | 0.86 | CYP2E1 (0.33) | CHEK1KDM4ECYP2E1HDAC1HDAC2 | |
| SCHEMBL5438174 | 0.86 | CYP2E1 (0.33) | CHEK1KDM4ECYP2E1HDAC1HDAC2 | |
| SCHEMBL5728400 | 0.84 | ACKR3 (0.32) | JAK2ACKR3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099929-A1 | Substituted thiophenes | AICURIS GMBH & CO. KG (DE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099929-A1 | Substituted thiophenes | TPMT, HAVCR2, MTAP | JAK2 554/4885CHEK1 2578/4885HSD17B1 2439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.