Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 13/20 | 0.55 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.55 |
| ▸ | TACR1 | P25103 | 5/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543034 | 0.91 | TACR1 (0.47) | ENPP2ATXN2TACR1SLC6A4 | |
| SCHEMBL543130 | 0.88 | ENPP2 (0.55) | ENPP2ATXN2TACR1KCNH2SLC13A3 | |
| SCHEMBL171688 | 0.87 | ENPP2 (0.53) | ENPP2ATXN2KCNH2 | |
| Hydrochloric Acid SCHEMBL34463580 | 0.86 | ENPP2 (0.52) | ENPP2ATXN2KCNH2 | |
| SCHEMBL543279 | 0.84 | ENPP2 (0.50) | ENPP2ATXN2KCNH2 | |
| SCHEMBL16129902 | 0.82 | ENPP2 (0.46) | ENPP2ATXN2TACR1SLC6A4KCNH2 | |
| SCHEMBL543007 | 0.81 | MEN1 (0.54) | ENPP2ATXN2TACR1SLC6A4 | |
| SCHEMBL542988 | 0.81 | ENPP2 (0.48) | ENPP2ATXN2KCNH2 | |
| SCHEMBL542664 | 0.81 | ENPP2 (0.52) | ENPP2ATXN2TACR1KCNH2 | |
| SCHEMBL16129852 | 0.81 | ENPP2 (0.45) | ENPP2ATXN2TACR1SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | claimed |
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | disclosed |