Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 6/20 | 0.79 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.55 |
| ▸ | EDNRB | P24530 | 2/20 | 0.49 |
| ▸ | EDNRA | P25101 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4892537 | 0.89 | SERPINE1 (1.00) | SERPINE1MAPK8EDNRBEDNRAMEN1 | |
| SCHEMBL5424000 | 0.88 | SERPINE1 (0.62) | SERPINE1MAPK8EDNRBEDNRALMNA | |
| SCHEMBL5417724 | 0.86 | SERPINE1 (0.60) | SERPINE1MAPK8EDNRBEDNRALMNA | |
| SCHEMBL4887004 | 0.84 | SERPINE1 (1.00) | SERPINE1MAPK8EDNRBEDNRAMEN1 | |
| SCHEMBL5419800 | 0.84 | SERPINE1 (0.66) | SERPINE1MAPK8EDNRBEDNRALMNA | |
| SCHEMBL4893854 | 0.80 | SERPINE1 (1.00) | SERPINE1MAPK8MEN1KMT2AALDH1A1 | |
| SCHEMBL4884146 | 0.77 | SERPINE1 (1.00) | SERPINE1MAPK8EDNRBEDNRAHDAC1 | |
| SCHEMBL4884301 | 0.77 | SERPINE1 (0.80) | SERPINE1MAPK8EDNRBEDNRACCR2 | |
| SCHEMBL5426724 | 0.76 | EDNRB (0.52) | SERPINE1MAPK8EDNRBEDNRALMNA | |
| SCHEMBL4892523 | 0.76 | SERPINE1 (0.73) | SERPINE1MAPK8EDNRBEDNRAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299125-A1 | Substituted indoles | WYETH (US) | 2007-12-27 | — | — | US | claimed |
| US-7268159-B2 | Substituted indoles | WYETH (US) | 2007-09-11 | — | — | US | claimed |
| EP-1670758-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-21 | — | — | EP | claimed |
| US-20050113438-A1 | Substituted indoles | WYETH (US) | 2005-05-26 | — | — | US | claimed |
| WO-2005030717-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | WYETH (US) | 2005-04-07 | — | — | WO | claimed |
| US-20070299125-A1 | Substituted indoles | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
| US-7268159-B2 | Substituted indoles | WYETH (US) | 2007-09-11 | — | — | US | disclosed |
| EP-1670758-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050113438-A1 | Substituted indoles | WYETH (US) | 2005-05-26 | — | — | US | disclosed |
| WO-2005030717-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299125-A1 | Substituted indoles | IDO2, IDO1, INMT | SERPINE1 4834/4885MAPK8 3676/4885EDNRB 1106/4885 |
| US-20050113438-A1 | Substituted indoles | IDO2, IDO1, INMT | SERPINE1 4834/4885MAPK8 3676/4885EDNRB 1106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.