SCHEMBL5437478

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL5440513	0.90	EGFR (0.46)	ABCG2EGFRBRAFRAF1TGFBR1
	SCHEMBL5447665	0.90	EGFR (0.49)	ABCG2EGFRBRAFRAF1TGFBR1
	SCHEMBL5440546	0.85	EGFR (0.45)	EGFRBRAFRAF1TGFBR1GRM4
	SCHEMBL5446058	0.85	EGFR (0.45)	EGFRBRAFRAF1TGFBR1GRM4
	SCHEMBL4508756	0.84	EGFR (0.59)	ABCG2EGFRTGFBR1GRM4ERBB2
	SCHEMBL5450861	0.81	ABCG2 (0.53)	ABCG2BRAFRAF1PIK3CDCDC7
	SCHEMBL5440941	0.81	BRAF (0.45)	ABCG2BRAFRAF1PIK3CDCDC7
	SCHEMBL5450874	0.81	LRRK2 (0.46)	ABCG2EGFRBRAFRAF1PIK3CD
	SCHEMBL5448685	0.80	BRAF (0.49)	ABCG2EGFRBRAFRAF1PIK3CD
	SCHEMBL5440959	0.80	EGFR (0.47)	EGFRTGFBR1GRM4ERBB2ERBB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.