Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 18/20 | 0.49 |
| ▸ | PPARG | P37231 | 18/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543486 | 0.91 | PGR (0.58) | PGRADORA3CHRM1TBXA2RPTGS1 | |
| SCHEMBL542796 | 0.86 | PGR (0.59) | PGRADORA3CHRM1TBXA2RPTGS1 | |
| SCHEMBL543517 | 0.85 | PPARA (0.59) | PGRADORA3CHRM1TBXA2RPTGS1 | |
| SCHEMBL543852 | 0.85 | PGR (0.58) | PGRADORA3CHRM1TBXA2RPTGS1 | |
| SCHEMBL6076481 | 0.84 | PGR (0.59) | PGRADORA3CHRM1TBXA2RPTGS1 | |
| SCHEMBL543830 | 0.84 | PPARG (0.67) | PGRADORA3CHRM1TBXA2RPTGS1 | |
| SCHEMBL543853 | 0.82 | PGR (0.58) | PGRADORA3CHRM1TBXA2RPTGS1 | |
| SCHEMBL543000 | 0.82 | PGR (0.61) | PGRADORA3CHRM1TBXA2RPTGS1 | |
| SCHEMBL543817 | 0.82 | PGR (0.70) | PGRADORA3CHRM1TBXA2RPTGS1 | |
| SCHEMBL543221 | 0.82 | PGR (0.70) | PGRADORA3CHRM1TBXA2RPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110598-B2 | (+-) Ethyl 3-{4-[2-(pyrrol-1-yl)ethoxy]phenyl}-2-ethoxypropanoate; hyperlipidaemia, hypercholesteremia, hyperglycemia, obesity, impaired glucose intolerance, leptin resistance, insulin resistance, reducing plasma glucose, triglycerides, total cholesterol, LDL, VLDL or free fatty acids in the plasma | CADILA HEALTHCARE LIMITED (IN) | 2012-02-07 | — | — | US | claimed |