Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 2/20 | 0.39 |
| ▸ | TGM1 | P22735 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5446141 | 0.89 | TGM2 (0.47) | PKMLMNATSHRKDM4EKMT2A | |
| SCHEMBL14490222 | 0.88 | TGM2 (0.54) | ALDH1A1LMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL14501664 | 0.88 | MEN1 (0.47) | ALDH1A1PKMLMNAHTTSMN1; SMN2 | |
| SCHEMBL5442020 | 0.85 | TGM2 (0.48) | SMN1; SMN2TGM2TGM1F13A1 | |
| SCHEMBL5440818 | 0.82 | F13A1 (0.47) | ALDH1A1PKMLMNAHTTSMN1; SMN2 | |
| SCHEMBL5453894 | 0.80 | TGM2 (0.47) | TGM2TGM1F13A1 | |
| SCHEMBL14490218 | 0.79 | TGM2 (0.54) | TGM2TGM1F13A1 | |
| SCHEMBL5452245 | 0.77 | F13A1 (0.47) | ALDH1A1PKMTGM2TGM1F13A1 | |
| SCHEMBL14501663 | 0.76 | MAPT (0.48) | ALDH1A1LMNAHTTTSHRKDM4E | |
| SCHEMBL5443780 | 0.75 | ABL1 (0.61) | ALDH1A1PKMYAP1TEAD4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149508-A1 | Six membered heteroaromatic inhibitors targeting resistant kinase mutations | TARGEGEN, INC. (US) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149508-A1 | Six membered heteroaromatic inhibitors targeting resistant kinase mutations | ABL1, KDR, BCR | ALDH1A1 3322/4885PKM 1319/4885YAP1 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.