Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5439968 | 0.87 | MEN1 (0.73) | MEN1KMT2ASMN1; SMN2HTTMAPT | |
| SCHEMBL5441202 | 0.85 | MEN1 (0.57) | MEN1KMT2ASMN1; SMN2HTTMAPT | |
| SCHEMBL3467489 | 0.78 | MEN1 (0.76) | MEN1KMT2ASMN1; SMN2HTTMAPT | |
| SCHEMBL3468752 | 0.78 | HTT (0.62) | MEN1KMT2ASMN1; SMN2HTTMAPT | |
| SCHEMBL5440007 | 0.75 | KMT2A (0.61) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL5446613 | 0.74 | MEN1 (0.69) | MEN1KMT2ASMN1; SMN2HTTMAPT | |
| SCHEMBL4111390 | 0.74 | SMN1; SMN2 (0.75) | MEN1KMT2ASMN1; SMN2HTTMAPT | |
| SCHEMBL2184232 | 0.73 | MEN1 (0.84) | MEN1KMT2ASMN1; SMN2HTTMAPT | |
| SCHEMBL5456028 | 0.73 | MEN1 (0.78) | MEN1KMT2ASMN1; SMN2HTTMAPT | |
| SCHEMBL3467876 | 0.73 | SMN1; SMN2 (0.58) | MEN1KMT2ASMN1; SMN2HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | RAF1, ARAF, JAK1 | MEN1 1756/4885KMT2A 1865/4885SMN1; SMN2 3543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.