Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5394670 | 0.87 | TTK (0.54) | SMN1; SMN2CNR1LMNANAMPTCD274 | |
| SCHEMBL5399718 | 0.83 | TTK (0.52) | SMN1; SMN2CNR1LMNANAMPTTTK | |
| SCHEMBL4655966 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2CNR1LMNAMAPTTTK | |
| SCHEMBL5404932 | 0.79 | TTK (0.56) | CNR1MAPTTTK | |
| SCHEMBL5398230 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTTTKMAPKAPK5KDR | |
| SCHEMBL5617938 | 0.78 | TTK (0.55) | CNR1NAMPTTTKTSHR | |
| SCHEMBL5404519 | 0.77 | EGFR (0.48) | SMN1; SMN2CNR1LMNAEPHX2KDR | |
| SCHEMBL5618519 | 0.76 | AURKA (0.48) | MAPTTTKMAPKAPK5EPHX2KDR | |
| SCHEMBL5618772 | 0.76 | TTK (0.53) | CNR1TTKMAPKAPK5 | |
| SCHEMBL4710603 | 0.75 | MAPT (0.47) | SMN1; SMN2MAPTTTKMAPKAPK5KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157460-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20040220189-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhbitors | SUGEN, INC. | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220189-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhbitors | MAP3K8, MAP4K4, MAP3K2 | SMN1; SMN2 4179/4885CNR1 1894/4885LMNA 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.