Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5449198 | 0.89 | CDK8 (0.53) | KDRRAF1CDK8RIPK1KIT | |
| SCHEMBL5436578 | 0.83 | KDR (0.64) | KDRCDK8RIPK1KITPDGFRB | |
| SCHEMBL5440740 | 0.80 | RIPK1 (0.51) | KDRCA1CA2CA9RIPK1 | |
| SCHEMBL27673022 | 0.80 | KDR (0.41) | KDR | |
| SCHEMBL14191797 | 0.80 | KIT (0.58) | KDRRAF1CDK8CA1CA2 | |
| SCHEMBL5105069 | 0.80 | RIPK1 (0.58) | KDRRAF1CDK8CA1CA2 | |
| SCHEMBL14191796 | 0.80 | KIT (0.60) | KDRRAF1CDK8CA1CA2 | |
| Hydrochloric Acid SCHEMBL5105968 | 0.79 | KIT (0.57) | KDRRAF1CDK8CA1CA2 | |
| Hydrochloric Acid SCHEMBL5120545 | 0.79 | KIT (0.59) | KDRRAF1CDK8CA1CA2 | |
| SCHEMBL5120556 | 0.79 | RIPK1 (0.59) | KDRRAF1CDK8CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | claimed |
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225347-A1 | Imidazole Derivatives | TIE1, FLT1, FER | KDR 4/4885RAF1 11/4885CDK8 545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.