SCHEMBL5443291

SCHEMBL5443291

O=c1ccn([C@H]2O[C@@H](COF)C(O)C2O)c(=O)[nH]1

nearest known ligand 0.72

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SLC28A1 O00337 1/20 0.72
SLC28A2 O43868 1/20 0.72
SLC29A1 Q99808 1/20 0.72
SLC28A3 Q9HAS3 1/20 0.72
P2RY6 Q15077 8/20 0.69
P2RY2 P41231 13/20 0.68
P2RY4 P51582 5/20 0.68
P2RY14 Q15391 5/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4948478 0.90 SLC28A1 (0.69) SLC28A1SLC28A2SLC29A1SLC28A3P2RY6
SCHEMBL6369206 0.90 SLC28A1 (0.72) SLC28A1SLC28A2SLC29A1SLC28A3P2RY6
SCHEMBL2168191 0.89 SLC28A1 (0.70) SLC28A1SLC28A2SLC29A1SLC28A3P2RY6
SCHEMBL6053985 0.88 SLC28A1 (0.74) SLC28A1SLC28A2SLC29A1SLC28A3P2RY6
SCHEMBL425155 0.88 SLC28A1 (0.74) SLC28A1SLC28A2SLC29A1SLC28A3P2RY6
SCHEMBL5846586 0.88 SLC28A1 (0.74) SLC28A1SLC28A2SLC29A1SLC28A3P2RY6
SCHEMBL17627530 0.88 SLC28A1 (0.66) SLC28A1SLC28A2SLC29A1SLC28A3P2RY6
SCHEMBL42134 0.87 SLC28A1 (0.72) SLC28A1SLC28A2SLC29A1SLC28A3P2RY6
SCHEMBL7618891 0.87 SLC28A1 (0.72) SLC28A1SLC28A2SLC29A1SLC28A3P2RY6
SCHEMBL566229 0.87 SLC28A1 (0.72) SLC28A1SLC28A2SLC29A1SLC28A3P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146286-A1 SMALL RNA-BASED PROGNOSTIC SIGNATURES AND THERAPEUTIC COMPOSITIONS FOR IDIOPATHIC PULMONARY FIBROSIS GATEHOUSE BIO INC. (US) 2026-05-28 US disclosed
WO-2024015640-A2 SMALL RNA-BASED PROGNOSTIC SIGNATURES AND THERAPEUTIC COMPOSITIONS FOR CORONARY MICROVASCULAR DYSFUNCTION GATEHOUSE BIO, INC. (US) 2024-01-18 WO disclosed
EP-2900679-B1 5-FLUOROURIDINE DERIVATIVES BRAUN MELSUNGEN AG (DE) 2020-07-01 EP disclosed
US-9914914-B2 Polymerase capable of producing non-DNA nucleotide polymers MEDICAL RESEARCH COUNCIL (GB) 2018-03-13 US disclosed
US-9902752-B2 5-fluorouracil derivatives B. BRAUN MELSUNGEN AG (DE) 2018-02-27 US disclosed
US-9486521-B2 Therapeutic applications targeting SARM1 UNIVERSITY OF MASSACHUSETTS (US) 2016-11-08 US disclosed
US-20150291649-A1 5-Fluorouracil Derivatives B. BRAUN MELSUNGEN AG (DE) 2015-10-15 US disclosed
US-20150275192-A1 POLYMERASE CAPABLE OF PRODUCING NON-DNA NUCLEOTIDE POLYMERS UNITED KINGDOM RESEARCH AND INNOVATION (GB) 2015-10-01 US disclosed
EP-2900679-A1 5-FLUORUORACIL DERIVATIVES B. Braun Melsungen AG (DE) 2015-08-05 EP disclosed
US-20140079712-A1 Therapeutic Applications Targeting SARM1 UNIVERSITY OF MIAMI (US) 2014-03-20 US disclosed
US-20070204357-A1 Process for producing normal parenchymal cells, tissues or organs by bioincubator YUKI ATSUSHI 2007-08-30 US disclosed
US-20040072350-A1 Process for producing normal parenchymal cells tissue or organ by bioincubator DIAMOND, PAUL 2004-04-15 US disclosed
EP-1135022-A4 PLASTIN PROMOTER DIRECTED GENE THERAPY UNIV YALE (US) 2003-07-09 EP disclosed
EP-1323821-A1 PROCESS FOR PRODUCING NORMAL PARENCHYMAL CELLS, TISSUE OR ORGAN BY BIOINCUBATOR Yuki, Atsushi (JP) 2003-07-02 EP disclosed
EP-1135022-A1 PLASTIN PROMOTER DIRECTED GENE THERAPY YALE UNIVERSITY (US) 2001-09-26 EP disclosed
EP-1060182-A2 NOVEL PRODRUGS FOR PHOSPHORUS-CONTAINING COMPOUNDS Metabasis Therapeutics, Inc. (US) 2000-12-20 EP disclosed
WO-2000033655-A1 PLASTIN PROMOTER DIRECTED GENE THERAPY YALE UNIVERSITY (US) 2000-06-15 WO disclosed
WO-1999045016-A9 NOVEL PRODRUGS FOR PHOSPHORUS-CONTAINING COMPOUNDS METABASIS THERAPEUTICS INC (US) 2000-03-02 WO disclosed
WO-1999045016-A2 NOVEL PRODRUGS FOR PHOSPHORUS-CONTAINING COMPOUNDS METABASIS THERAPEUTICS, INC. (US) 1999-09-10 WO disclosed
US-5849905-A Biologically active phosphotriester-type nucleosides and methods for preparing same CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1998-12-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150291649-A1 5-Fluorouracil Derivatives DPYD, FAU, DHFR SLC28A1 1007/4885SLC28A2 1074/4885SLC29A1 473/4885
US-20260146286-A1 SMALL RNA-BASED PROGNOSTIC SIGNATURES AND THERAPEUTIC COMPOSITIONS FOR IDIOPATHIC PULMONARY FIBROSIS RBM26, RBM28, RBM25 SLC28A1 370/4885SLC28A2 488/4885SLC29A1 424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.