Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 4/20 | 0.37 |
| ▸ | BRAF | P15056 | 4/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 7/20 | 0.33 |
| ▸ | TEK | Q02763 | 5/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5450818 | 0.86 | RIPK1 (0.41) | RIPK1RAF1BRAFDYRK1ADYRK1B | |
| SCHEMBL5459650 | 0.85 | RAF1 (0.43) | RIPK1RAF1BRAFDYRK1ADYRK1B | |
| SCHEMBL5455201 | 0.81 | RIPK1 (0.40) | RIPK1RAF1BRAFDYRK1ADYRK1B | |
| SCHEMBL5458915 | 0.80 | KDR (0.35) | RAF1BRAFDYRK1ADYRK1BNPC1 | |
| SCHEMBL5453181 | 0.80 | RIPK1 (0.40) | RIPK1RAF1BRAFDYRK1ADYRK1B | |
| SCHEMBL5447363 | 0.74 | CSNK1D (0.35) | RAF1BRAFDYRK1ADYRK1BKDR | |
| SCHEMBL5447181 | 0.74 | RAF1 (0.44) | RAF1BRAFDYRK1ADYRK1BKDR | |
| SCHEMBL14595257 | 0.74 | RIPK1 (0.43) | RIPK1RAF1BRAFDYRK1ADYRK1B | |
| SCHEMBL5449925 | 0.74 | KDR (0.49) | RAF1BRAFDYRK1ADYRK1BKDR | |
| SCHEMBL5444075 | 0.73 | KDR (0.41) | RAF1BRAFKDRTEKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021456-A1 | Aminobenzimidazole derivatives | MERCK PATENT GMBH (DE) | 2007-01-25 | — | — | US | claimed |
| US-20070021456-A1 | Aminobenzimidazole derivatives | MERCK PATENT GMBH (DE) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021456-A1 | Aminobenzimidazole derivatives | TIE1, KDR, FLT1 | RIPK1 1867/4885RAF1 17/4885BRAF 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.