SCHEMBL544524

SCHEMBL544524

c1c[nH]c(/N=N/c2ccc[nH]2)c1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
AURKA O14965 1/20 0.35
AURKB Q96GD4 1/20 0.35
INCENP Q9NQS7 1/20 0.35
FKBP5 Q13451 1/20 0.33
GRIN2D O15399 1/20 0.31
GRIN3B O60391 1/20 0.31
GRIN1 Q05586 1/20 0.31
GRIN2A Q12879 1/20 0.31
GRIN2B Q13224 1/20 0.31
GRIN2C Q14957 1/20 0.31
GRIN3A Q8TCU5 1/20 0.31
MCL1 Q07820 1/20 0.31
NAPRT Q6XQN6 1/20 0.31
KDM4E B2RXH2 1/20 0.30
GAA P10253 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL544525 1.00 DAO (0.35) DAOHDAC8HDAC6AURKAAURKB
SCHEMBL14337371 0.84
SCHEMBL3194313 0.81 DAO (0.35) DAOHDAC8HDAC6AURKAAURKB
SCHEMBL20280328 0.78 MAPT (0.61) DAOHDAC8HDAC6KDM4EGAA
SCHEMBL3221479 0.77
SCHEMBL967615 0.77
SCHEMBL19921043 0.76 ALDH1A1 (0.36)
SCHEMBL14337293 0.73 ALDH1A1 (0.33) GAA
SCHEMBL78890 0.71
SCHEMBL2776642 0.71 ALDH1A1 (0.38) FKBP5NAPRTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 179 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4355792-A2 TRIAZOLE CONTAINING POLYMERS AND METHODS OF USE THEREOF William Marsh Rice University (US) 2024-04-24 EP disclosed
EP-4320170-A1 INTERFACIAL SEEDING OF CELLS AND PARTICLES ON SURFACES FOR DIAGNOSTICS AND THERAPEUTICS William Marsh Rice University (US) 2024-02-14 EP disclosed
CN-117244109-A Vascularization device and method for implantable diagnosis and treatment 威廉马歇莱思大学 2023-12-19 CN disclosed
CN-113825531-B Vascularization device and method for implantable diagnosis and treatment 威廉马歇莱思大学 2023-07-25 CN disclosed
US-20230210908-A1 METHODS FOR IMPROVED DELIVERY OF THERAPEUTIC AGENTS WILLIAM MARSH RICE UNIVERSITY (US) 2023-07-06 US disclosed
US-20230130084-A1 MODIFIED ALGINATES FOR CELL ENCAPSULATION AND CELL THERAPY MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2023-04-27 US disclosed
US-20230054899-A1 HIGH THROUGHPUT GENETIC BARCODING AND ANALYSIS METHODS WILLIAM MARSH RICE UNIVERSITY (US) 2023-02-23 US disclosed
WO-2022266086-A2 TRIAZOLE CONTAINING POLYMERS AND METHODS OF USE THEREOF WILLIAM MARSH RICE UNIVERSITY (US) 2022-12-22 WO disclosed
EP-4103237-A1 METHODS FOR IMPROVED DELIVERY OF THERAPEUTIC AGENTS William Marsh Rice University (US) 2022-12-21 EP disclosed
US-20220333050-A1 INTERFACIAL SEEDING OF CELLS AND PARTICLES ON SURFACES FOR DIAGNOSTICS AND THERAPEUTICS WILLIAM MARSH RICE UNIVERSITY (US) 2022-10-20 US disclosed
WO-1996040304-A1 INJECTABLE HYDROGEL COMPOSITIONS REPROGENESIS, INC. (US) 1996-12-19 WO disclosed
EP-0299010-B1 CHIMERIC NEOMORPHOGENESIS OF ORGANS BY CONTROLLED CELLULAR IMPLANTATION USING ARTIFICIAL MATRICES CHILDRENS MEDICAL CENTER (US) 1996-06-19 EP disclosed
EP-0708662-A1 INJECTABLE POLYSACCHARIDE-CELL COMPOSITIONS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1996-05-01 EP disclosed
WO-1994025079-A1 POROUS BIODEGRADABLE POLYMERIC MATERIALS FOR CELL TRANSPLANTATION MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1994-11-10 WO disclosed
WO-1994025080-A1 INJECTABLE POLYSACCHARIDE-CELL COMPOSITIONS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1994-11-10 WO disclosed
EP-0610423-A1 PREVASCULARIZED POLYMERIC IMPLANTS FOR ORGAN TRANSPLANTATION. MASSACHUSETTS INST TECHNOLOGY (US) 1994-08-17 EP disclosed
WO-1993008850-A1 PREVASCULARIZED POLYMERIC IMPLANTS FOR ORGAN TRANSPLANTATION MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1993-05-13 WO disclosed
EP-0299010-A4 CHIMERIC NEOMORPHOGENESIS OF ORGANS BY CONTROLLED CELLULAR IMPLANTATION USING ARTIFICIAL MATRICES. VACANTI JOSEPH P (US) 1990-01-26 EP disclosed
EP-0299010-A1 CHIMERIC NEOMORPHOGENESIS OF ORGANS BY CONTROLLED CELLULAR IMPLANTATION USING ARTIFICIAL MATRICES. VACANTI JOSEPH P (US) 1989-01-18 EP disclosed
WO-1988003785-A1 CHIMERIC NEOMORPHOGENESIS OF ORGANS BY CONTROLLED CELLULAR IMPLANTATION USING ARTIFICIAL MATRICES VACANTI JOSEPH P (US) 1988-06-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230130084-A1 MODIFIED ALGINATES FOR CELL ENCAPSULATION AND CELL THERAPY ALG1, CD44, CD47 DAO 2317/4885HDAC8 612/4885HDAC6 36/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.