Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 7/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | CCL2 | P13500 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | PRKACG | P22612 | 1/20 | 0.42 |
| ▸ | PRKACB | P22694 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5445592 | 1.00 | CA12 (0.44) | CA12ABL1CA2NAMPTPRKCQ | |
| SCHEMBL5446188 | 0.97 | IKBKB (0.44) | CA12ABL1CA2PRKCQPRKCD | |
| SCHEMBL5446183 | 0.97 | IKBKB (0.44) | CA12ABL1CA2PRKCQPRKCD | |
| SCHEMBL5442262 | 0.89 | PRKCQ (0.45) | PRKCQPRKCDIKBKBCHUKSRC | |
| SCHEMBL5442265 | 0.89 | PRKCQ (0.45) | PRKCQPRKCDIKBKBCHUKSRC | |
| SCHEMBL5442204 | 0.88 | CA12 (0.44) | CA12ABL1CA2NAMPTPRKCQ | |
| SCHEMBL5442201 | 0.88 | CA12 (0.44) | CA12ABL1CA2NAMPTPRKCQ | |
| SCHEMBL5442125 | 0.86 | PRKCQ (0.42) | NAMPTPRKCQPRKCDIKBKBCHUK | |
| SCHEMBL5442129 | 0.86 | PRKCQ (0.42) | NAMPTPRKCQPRKCDIKBKBCHUK | |
| SCHEMBL5442216 | 0.85 | IKBKB (0.44) | CA12ABL1CA2NAMPTIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149508-A1 | Six membered heteroaromatic inhibitors targeting resistant kinase mutations | TARGEGEN, INC. (US) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149508-A1 | Six membered heteroaromatic inhibitors targeting resistant kinase mutations | ABL1, KDR, BCR | CA12 4807/4885ABL1 1/4885CA2 4647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.