Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.68 |
| ▸ | CA1 | P00915 | 1/20 | 0.68 |
| ▸ | CA2 | P00918 | 1/20 | 0.68 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.68 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.68 |
| ▸ | ITGAL | P20701 | 1/20 | 0.68 |
| ▸ | CA4 | P22748 | 1/20 | 0.68 |
| ▸ | CA6 | P23280 | 1/20 | 0.68 |
| ▸ | AHR | P35869 | 1/20 | 0.68 |
| ▸ | ADK | P55263 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL9418736 | 0.85 | TRPA1 (0.59) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL2948635 | 0.85 | TRPA1 (0.59) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL27647341 | 0.85 | TRPA1 (0.59) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL6791278 | 0.85 | AHR (0.85) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL15007820 | 0.85 | AHR (0.85) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL8213935 | 0.85 | AHR (0.85) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL28020016 | 0.85 | AHR (0.85) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL2769465 | 0.85 | AHR (0.85) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL28042366 | 0.85 | AHR (0.85) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL27856435 | 0.85 | TRPA1 (0.63) | TRPA1CA1CA2ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070073060-A1 | Tricycle indole hydroxyethlamine derivatives and their use in the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-03-29 | — | — | US | disclosed |
| CN-1914214-A | Tricycle indole hydroxyethlamine derivatives and their use in the treatment of alzheimer's disease | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070073060-A1 | Tricycle indole hydroxyethlamine derivatives and their use in the treatment of alzheimer's disease | BACE2, BACE1, APP | TRPA1 3263/4885CA1 2612/4885CA2 3337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.