Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 6/20 | 0.52 |
| ▸ | CDK2 | P24941 | 6/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.52 |
| ▸ | AURKA | O14965 | 11/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5454557 | 0.90 | AURKA (0.55) | CCNA2CDK2CCNA1AURKAAURKB | |
| SCHEMBL5463668 | 0.89 | CCNA2 (0.52) | CCNA2CDK2CCNA1AURKANTRK1 | |
| SCHEMBL5454686 | 0.85 | CCNA2 (0.53) | CCNA2CDK2CCNA1AURKANTRK1 | |
| SCHEMBL5456511 | 0.85 | CCNA2 (0.56) | CCNA2CDK2CCNA1AURKANTRK1 | |
| SCHEMBL5451393 | 0.84 | NFKB1 (0.44) | CCNA2CDK2CCNA1AURKASCN9A | |
| SCHEMBL5447000 | 0.80 | CCNA2 (0.56) | CCNA2CDK2CCNA1AURKANTRK1 | |
| SCHEMBL5453835 | 0.79 | CCNA2 (0.52) | CCNA2CDK2CCNA1AURKANTRK1 | |
| SCHEMBL5459347 | 0.79 | AURKA (0.61) | CCNA2CDK2CCNA1AURKANTRK1 | |
| SCHEMBL5453857 | 0.78 | CDK2 (0.53) | CCNA2CDK2CCNA1AURKANTRK1 | |
| SCHEMBL5451846 | 0.77 | CDK2 (0.50) | CCNA2CDK2CCNA1AURKANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037790-A1 | Bicyclo-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2007-02-15 | — | — | US | claimed |
| US-20070037790-A1 | Bicyclo-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037790-A1 | Bicyclo-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K15, MAP3K7, MAP3K19 | CCNA2 1123/4885CDK2 65/4885CCNA1 915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.