Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 5/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831352 | 0.88 | POLB (0.56) | MAPTMEN1KMT2AL3MBTL1GAA | |
| Ammonia Solution, Strong SCHEMBL5449039 | 0.87 | POLB (0.55) | MAPTMEN1KMT2AL3MBTL1GAA | |
| SCHEMBL29022580 | 0.87 | POLB (0.55) | MAPTMEN1KMT2AL3MBTL1GAA | |
| SCHEMBL30390032 | 0.87 | POLB (0.55) | MAPTMEN1KMT2AL3MBTL1GAA | |
| SCHEMBL28753724 | 0.79 | GAA (0.48) | MAPTMEN1KMT2AL3MBTL1GAA | |
| SCHEMBL17817254 | 0.71 | POLB (0.48) | MAPTMEN1KMT2AL3MBTL1GAA | |
| SCHEMBL124721 | 0.69 | GAA (0.65) | MAPTMEN1KMT2AL3MBTL1GAA | |
| SCHEMBL6720846 | 0.68 | POLB (0.48) | MAPTMEN1KMT2AL3MBTL1GAA | |
| SCHEMBL28753721 | 0.67 | POLB (0.57) | MAPTMEN1KMT2AL3MBTL1POLB | |
| SCHEMBL14429913 | 0.65 | MAPT (0.48) | MAPTMEN1KMT2AL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185176-A1 | Heparanase inhibitors and uses thereof | INSIGHT BIOHARMACEUTICALS LTD. (IL) | 2007-08-09 | — | — | US | disclosed |
| EP-1720828-A2 | HEPARANASE INHIBITORS AND USES THEREOF | Insight Biopharmaceuticals Ltd (IL) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005074375-A2 | HEPARANASE INHIBITORS AND USES THEREOF | INSIGHT BIOPHARMACEUTICALS LTD (IL) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185176-A1 | Heparanase inhibitors and uses thereof | HPSE, ENGASE, HEXA | MAPT 4234/4885MEN1 2391/4885KMT2A 2842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.