Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 10/20 | 0.42 |
| ▸ | HTR1B | P28222 | 10/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5448061 | 0.91 | HTR1A (0.48) | HTR1ADRD2TMEM97SIGMAR1HTR1D | |
| SCHEMBL5458682 | 0.89 | HTR1A (0.49) | HTR1ADRD2TMEM97SIGMAR1HTR1D | |
| SCHEMBL5452400 | 0.88 | HTR1A (0.51) | HTR1ADRD2TMEM97SIGMAR1HTR1D | |
| SCHEMBL5461519 | 0.88 | HTR1A (0.46) | HTR1ADRD2TMEM97SIGMAR1HTR1D | |
| SCHEMBL5458753 | 0.87 | HTR1A (0.49) | HTR1ADRD2TMEM97SIGMAR1HTR1D | |
| SCHEMBL5447987 | 0.86 | TMEM97 (0.46) | HTR1ADRD2TMEM97SIGMAR1HTR1D | |
| SCHEMBL5452259 | 0.85 | MAPT (0.46) | HTR1ADRD2TMEM97SIGMAR1HTR1D | |
| SCHEMBL5451050 | 0.85 | HTR1A (0.42) | HTR1ADRD2TMEM97SIGMAR1HTR1D | |
| SCHEMBL5445015 | 0.85 | NPC1 (0.58) | HTR1ADRD2TMEM97SIGMAR1HTR1D | |
| Ammonia Solution, Strong SCHEMBL5452545 | 0.84 | MAPT (0.46) | HTR1ADRD2TMEM97SIGMAR1HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010526-A1 | Therapeutic isoquinoline compounds | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
| US-20070010526-A1 | Therapeutic isoquinoline compounds | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
| US-20070010526-A1 | Therapeutic isoquinoline compounds | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
| EP-1451172-A1 | THERAPEUTIC ISOQUINOLINE COMPOUNDS | AstraZeneca AB (SE) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003037887-A1 | THERAPEUTIC ISOQUINOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010526-A1 | Therapeutic isoquinoline compounds | HTR1B, HTR1D, HTR1A | HTR1A 3/4885DRD2 27/4885TMEM97 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.