Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 15/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6850885 | 0.97 | SIGMAR1 (0.65) | SIGMAR1MEN1KMT2ACSNK1E | |
| SCHEMBL21175470 | 0.90 | SIGMAR1 (0.70) | SIGMAR1MEN1KMT2ACSNK1E | |
| SCHEMBL9415949 | 0.89 | SIGMAR1 (0.60) | SIGMAR1MEN1KMT2ACSNK1E | |
| Hydrochloric Acid SCHEMBL5616415 | 0.87 | SIGMAR1 (0.58) | SIGMAR1MEN1KMT2ACSNK1E | |
| SCHEMBL25590992 | 0.86 | SIGMAR1 (0.57) | SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9249699 | 0.82 | SIGMAR1 (0.67) | SIGMAR1MEN1KMT2A | |
| SCHEMBL29022562 | 0.81 | SIGMAR1 (0.59) | SIGMAR1MEN1KMT2ACSNK1E | |
| SCHEMBL3464964 | 0.81 | SIGMAR1 (0.77) | SIGMAR1 | |
| SCHEMBL28294948 | 0.79 | SIGMAR1 (0.53) | SIGMAR1MEN1KMT2A | |
| SCHEMBL7170294 | 0.79 | SIGMAR1 (0.53) | SIGMAR1MEN1KMT2ACSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254320-A1 | Method and Kit for Detecting Listeria Spp. | OLSTEIN ALAN | 2007-11-01 | — | — | US | disclosed |
| WO-2005040754-A2 | METHOD AND KIT FOR DETECTING LISTERIA spp. | PARADIGM DIAGNOSTICS, INC. (US) | 2005-05-06 | — | — | WO | disclosed |
| US-5145772-A | FLUOROPHORES | TROPIX, INC. (US) | 1992-09-08 | — | — | US | disclosed |