SCHEMBL5450877

SCHEMBL5450877

C=CC[Si](C)(CC)OC(C)=O

nearest known ligand 0.30

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2283499 0.79 HSD17B10 (0.35) ALDH1A1HSD17B10
SCHEMBL27710225 0.78 ALDH1A1 (0.31) ALDH1A1LMNAHSD17B10
SCHEMBL545209 0.77 ALDH1A1 (0.32) ALDH1A1LMNA
SCHEMBL127638 0.74 ALDH1A1 (0.33) ALDH1A1
SCHEMBL699755 0.74 ALDH1A1 (0.33) ALDH1A1
SCHEMBL14956851 0.72
SCHEMBL5444305 0.71 ALDH1A1 (0.32) ALDH1A1LMNAHSD17B10
SCHEMBL1493144 0.71 USP2 (0.31) ALDH1A1LMNA
SCHEMBL9722123 0.71 ALDH1A1 (0.31) ALDH1A1
SCHEMBL9722203 0.71 ALDH1A1 (0.31) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070173935-A1 Nucleus pulposus augmentation pretreatment technique DEPUY SPINE, INC. 2007-07-26 US claimed
US-20070173935-A1 Nucleus pulposus augmentation pretreatment technique DEPUY SPINE, INC. 2007-07-26 US disclosed