SCHEMBL5452383

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL8289504	0.86	NPC1 (0.63)	LMNASMN1; SMN2CFTRPOLBCASP6
	SCHEMBL5458883	0.86	POLB (0.63)	LMNASMN1; SMN2CFTRPOLBCASP6
	SCHEMBL5460380	0.83	CFTR (0.60)	SMN1; SMN2CFTRPTPRCPTPN2PTPN1
	SCHEMBL5466126	0.81	CFTR (0.57)	SMN1; SMN2CFTRPTPRCPTPN2PTPN1
	SCHEMBL5457615	0.80	CFTR (0.50)	SMN1; SMN2CFTRRAB7APTPRCPTPN2
	SCHEMBL5455947	0.79	MEN1 (0.65)	LMNACFTRRAB7APTPRCPTPN2
	SCHEMBL5450939	0.78	CFTR (0.54)	SMN1; SMN2CFTRPTPRCPTPN2PTPN1
	SCHEMBL5452074	0.78	CFTR (0.56)	SMN1; SMN2CFTRPTPRCPTPN2PTPN1
	SCHEMBL14361079	0.78	CFTR (0.56)	SMN1; SMN2CFTRPTPRCPTPN2PTPN1
	SCHEMBL5451008	0.78	CFTR (0.59)	LMNACFTRRAB7APTPRCPTPN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.