Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14592091 | 0.88 | CSF1R (0.47) | MAPK14CSF1RFGFR1FLT1KDR | |
| SCHEMBL5451211 | 0.88 | MAPK14 (0.52) | MAPK14FYNPTGS2GRM5ALDH1A1 | |
| SCHEMBL5458670 | 0.87 | MAPK14 (0.41) | MAPK14CSF1RFGFR1FLT1KDR | |
| SCHEMBL5212963 | 0.85 | MAPK14 (0.54) | MAPK14FYNCSF1RFGFR1FLT1 | |
| SCHEMBL6105823 | 0.85 | ALDH1A1 (0.43) | MAPK14ALDH1A1KDM4EPTGER1 | |
| SCHEMBL5464020 | 0.84 | MAPK14 (0.51) | MAPK14PTGS2GRM5P2RX7RORC | |
| SCHEMBL5460475 | 0.84 | MAPK14 (0.53) | MAPK14PTGS2P2RX7RORCRARG | |
| SCHEMBL5458513 | 0.81 | MAPK14 (0.48) | MAPK14ALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL5458504 | 0.81 | MAPK14 (0.48) | MAPK14ALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL5457446 | 0.80 | MAPK14 (0.36) | MAPK14CSF1RFGFR1FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287721-A1 | Pyrazolopyridinyl pyridine | BOYD F LESLIE | 2007-12-13 | — | — | US | disclosed |
| EP-1341788-B1 | PYRAZOLOPYRIDINES | GLAXO GROUP LTD (GB) | 2005-08-10 | — | — | EP | disclosed |
| EP-1377573-B1 | PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-07-27 | — | — | EP | disclosed |
| US-6919352-B2 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-19 | — | — | US | disclosed |
| US-20040072853-A1 | Therapeutic compounds | CHAMBERLAIN STANLEY D (US) | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287721-A1 | Pyrazolopyridinyl pyridine | CYP3A5, CYP2C19, CYP3A4 | MAPK14 2533/4885FYN 929/4885PTGS2 802/4885 |
| US-20040072853-A1 | Therapeutic compounds | PCSK9, ABCB1, FURIN | MAPK14 4359/4885FYN 1441/4885PTGS2 374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.