Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTH1R | Q03431 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320380 | 0.90 | PTH1R (0.57) | PTH1RMAPTHTTPDE4APDE4B | |
| SCHEMBL5323873 | 0.88 | PTH1R (0.43) | PTH1RMAPTHTTPDE4APDE4B | |
| SCHEMBL5323786 | 0.88 | PTH1R (0.45) | PTH1RMAPTHTTPDE4APDE4B | |
| SCHEMBL5330994 | 0.88 | PTH1R (0.43) | PTH1RMAPTHTTPDE4APDE4B | |
| SCHEMBL5327453 | 0.87 | PTH1R (0.45) | PTH1RMAPTHTTPDE4APDE4B | |
| SCHEMBL5325577 | 0.86 | PTH1R (0.42) | PTH1RMAPTHTTPDE4APDE4B | |
| SCHEMBL5327910 | 0.83 | PTH1R (0.56) | PTH1RMAPTPDE4APDE4BPDE4C | |
| SCHEMBL5329426 | 0.82 | PTH1R (0.60) | PTH1RPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5320334 | 0.80 | PTH1R (0.69) | PTH1RMAPTAPPSNCAALDH1A1 | |
| SCHEMBL5324664 | 0.79 | PTH1R (0.58) | PTH1RACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |