Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.48 |
| ▸ | RAF1 | P04049 | 13/20 | 0.48 |
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545856 | 0.87 | RAF1 (0.59) | BRAFRAF1KDRDDR2 | |
| SCHEMBL546196 | 0.84 | BRAF (0.54) | BRAFRAF1KDR | |
| SCHEMBL546534 | 0.83 | BRAF (0.56) | BRAFRAF1KDR | |
| SCHEMBL546766 | 0.81 | RAF1 (0.61) | BRAFRAF1KDRDDR2 | |
| SCHEMBL10200174 | 0.80 | RAF1 (0.57) | BRAFRAF1KDR | |
| SCHEMBL545697 | 0.80 | BRAF (0.58) | BRAFRAF1KDR | |
| SCHEMBL546137 | 0.76 | BRAF (0.61) | BRAFRAF1KDR | |
| SCHEMBL545483 | 0.76 | HTR2A (0.44) | KDR | |
| SCHEMBL545253 | 0.76 | BRAF (0.58) | BRAFRAF1KDR | |
| SCHEMBL10262926 | 0.75 | BRAF (0.47) | BRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | claimed |