Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.59 |
| ▸ | BRAF | P15056 | 13/20 | 0.59 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546766 | 0.94 | RAF1 (0.61) | RAF1BRAFDDR2KDRSRC | |
| SCHEMBL10199990 | 0.87 | RAF1 (0.64) | RAF1BRAFDDR2KDRSRC | |
| SCHEMBL545489 | 0.87 | BRAF (0.48) | RAF1BRAFDDR2KDR | |
| SCHEMBL10262295 | 0.85 | RAF1 (0.56) | RAF1BRAFDDR2KDRSRC | |
| SCHEMBL14453616 | 0.83 | RAF1 (0.70) | RAF1BRAFDDR2KDRSRC | |
| SCHEMBL545800 | 0.82 | BRAF (0.72) | RAF1BRAFKDRSRC | |
| SCHEMBL545570 | 0.81 | DDR2 (0.53) | RAF1BRAFDDR2KDRSRC | |
| SCHEMBL169261 | 0.81 | DDR2 (0.74) | RAF1BRAFDDR2KDRSRC | |
| SCHEMBL546023 | 0.80 | BRAF (0.65) | RAF1BRAFDDR2KDRSRC | |
| SCHEMBL10200309 | 0.80 | BRAF (0.78) | RAF1BRAFDDR2KDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | claimed |