Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 7/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14453616 | 0.86 | RAF1 (0.70) | DDR2RAF1KDRMAPK14BRAF | |
| SCHEMBL169261 | 0.85 | DDR2 (0.74) | DDR2RAF1KDRMAPK14BRAF | |
| SCHEMBL545856 | 0.81 | RAF1 (0.59) | DDR2RAF1KDRBRAFSRC | |
| SCHEMBL545483 | 0.81 | HTR2A (0.44) | KDRKDM4EHTTKMT2AFGFR1 | |
| SCHEMBL546211 | 0.80 | KDR (0.68) | RAF1KDRMAPK14BRAFFGFR1 | |
| SCHEMBL14453610 | 0.80 | RAF1 (0.73) | DDR2RAF1KDRMAPK14BRAF | |
| SCHEMBL14453611 | 0.78 | RAF1 (0.70) | DDR2RAF1KDRMAPK14BRAF | |
| SCHEMBL170968 | 0.78 | DDR2 (0.68) | DDR2RAF1KDRMAPK14BRAF | |
| SCHEMBL16990634 | 0.77 | DDR2 (0.62) | DDR2RAF1KDRBRAFKDM4E | |
| SCHEMBL171038 | 0.76 | DDR2 (0.66) | DDR2RAF1KDRMAPK14MAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MAP3K20, MAP3K1, MAP3K5 | DDR2 1545/4885RAF1 198/4885KDR 1264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.