Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464881 | 0.82 | KDM4E (0.60) | KDM4EHRH3TMEM97SIGMAR1HTR1A | |
| SCHEMBL5459847 | 0.81 | HRH3 (0.45) | KDM4EHRH3TMEM97SIGMAR1HTR1A | |
| SCHEMBL5459085 | 0.79 | L3MBTL3 (0.52) | KDM4EHRH3TMEM97SIGMAR1HTR1A | |
| SCHEMBL5459697 | 0.79 | L3MBTL3 (0.57) | KDM4EHRH3TMEM97SIGMAR1HTR1A | |
| SCHEMBL5465885 | 0.79 | KDM4E (0.60) | KDM4EHRH3TMEM97SIGMAR1HTR1A | |
| SCHEMBL5457320 | 0.78 | HRH3 (0.44) | HRH3TMEM97SIGMAR1HTR1AHRH2 | |
| SCHEMBL5465760 | 0.78 | TSHR (0.50) | KDM4EHRH3TMEM97SIGMAR1HTR1A | |
| SCHEMBL5457290 | 0.78 | TMEM97 (0.47) | KDM4EHRH3TMEM97SIGMAR1HTR1A | |
| SCHEMBL5459964 | 0.78 | MEN1 (0.56) | KDM4EPKMHRH3TMEM97SIGMAR1 | |
| SCHEMBL5466137 | 0.78 | KDM4E (0.67) | KDM4EHRH3TMEM97SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | CNR2, GRIN2C, GRIN2B | ATM 2453/4885KDM4E 1975/4885PKM 1774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.