Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5451209 | 0.93 | MAPK14 (0.37) | MAPK14CSNK1DL3MBTL1ALOX5KDM4E | |
| SCHEMBL5457274 | 0.84 | MAPK14 (0.46) | MAPK14CSNK1DALOX5KDM4ETGFBR1 | |
| SCHEMBL5460496 | 0.84 | MAPK14 (0.46) | MAPK14CSNK1DALOX5KDM4EGSK3B | |
| SCHEMBL5455260 | 0.82 | MAPK14 (0.44) | MAPK14CSNK1DALOX5PTGS1PTGS2 | |
| SCHEMBL5462366 | 0.81 | MAPK14 (0.43) | MAPK14CSNK1DALOX5KDM4ETGFBR1 | |
| SCHEMBL5455132 | 0.80 | MAPK14 (0.48) | MAPK14CSNK1DL3MBTL1ALOX5KDM4E | |
| SCHEMBL5455164 | 0.80 | MAPK14 (0.48) | MAPK14CSNK1DALOX5KDM4EGSK3B | |
| SCHEMBL5459562 | 0.78 | MAPK14 (0.44) | MAPK14CSNK1DALOX5KDM4EPTGS1 | |
| SCHEMBL5448946 | 0.77 | MAPK14 (0.46) | MAPK14CSNK1DALOX5KDM4EGSK3B | |
| SCHEMBL6184414 | 0.77 | MAPK14 (0.43) | MAPK14CSNK1DKDM4EPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287721-A1 | Pyrazolopyridinyl pyridine | BOYD F LESLIE | 2007-12-13 | — | — | US | disclosed |
| EP-1377573-B1 | PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-07-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287721-A1 | Pyrazolopyridinyl pyridine | CYP3A5, CYP2C19, CYP3A4 | MAPK14 2533/4885CSNK1D 411/4885L3MBTL1 4885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.