Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.47 |
| ▸ | RAF1 | P04049 | 6/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4643326 | 0.84 | BRAF (0.54) | BRAFRAF1HDAC3HDAC8HDAC6 | |
| SCHEMBL545714 | 0.84 | KDM4E (0.52) | BRAFRAF1HDAC3HDAC8HDAC6 | |
| SCHEMBL5430598 | 0.82 | BRAF (0.68) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL5435294 | 0.82 | BRAF (0.49) | BRAFRAF1HDAC3HDAC8HDAC6 | |
| SCHEMBL5423590 | 0.82 | BRAF (0.62) | BRAFRAF1HDAC3HDAC8HDAC6 | |
| SCHEMBL544977 | 0.82 | BRAF (0.51) | BRAFRAF1HDAC3HDAC8HDAC6 | |
| SCHEMBL547348 | 0.82 | RAF1 (0.52) | BRAFRAF1HDAC3HDAC8HDAC6 | |
| SCHEMBL5426546 | 0.81 | BRAF (0.49) | BRAFRAF1HDAC3HDAC8HDAC6 | |
| SCHEMBL545643 | 0.81 | BRAF (0.54) | BRAFRAF1HDAC3HDAC8HDAC6 | |
| SCHEMBL10200809 | 0.80 | BRAF (0.51) | BRAFRAF1HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |