Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.52 |
| ▸ | BRAF | P15056 | 7/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.51 |
| ▸ | FLT1 | P17948 | 3/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.51 |
| ▸ | TTK | P33981 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545989 | 0.83 | KDR (0.58) | RAF1BRAFKDRRETFLT1 | |
| SCHEMBL545646 | 0.83 | RAF1 (0.56) | RAF1BRAFKDRRETFLT1 | |
| SCHEMBL10199708 | 0.82 | RAF1 (0.74) | RAF1BRAFKDRRETFLT1 | |
| SCHEMBL546771 | 0.82 | BRAF (0.57) | RAF1BRAFKDRRETFLT1 | |
| Hydrochloric Acid SCHEMBL545435 | 0.82 | RAF1 (0.55) | RAF1BRAFKDRRETFLT1 | |
| SCHEMBL545174 | 0.82 | RAF1 (0.58) | RAF1BRAFKDRRETFLT1 | |
| SCHEMBL545734 | 0.82 | BRAF (0.47) | RAF1BRAFKDRFLT1PDGFRB | |
| SCHEMBL10200762 | 0.81 | KDR (0.54) | RAF1BRAFKDRRETFLT1 | |
| SCHEMBL5435203 | 0.80 | HDAC1 (0.56) | RAF1BRAFKDRRETFLT1 | |
| SCHEMBL545637 | 0.79 | KDR (0.52) | RAF1BRAFKDRRETFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |