Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.64 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5462357 | 0.81 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL5476624 | 0.80 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ALDH1A1MAPTKDM4E | |
| SCHEMBL1781499 | 0.78 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL1985041 | 0.76 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL1985045 | 0.76 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL1782260 | 0.69 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL1782262 | 0.69 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL12075117 | 0.69 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL1781492 | 0.68 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL4619855 | 0.68 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | TK1, TK2, SLC1A5 | HSP90AA1 3373/4885HSP90AB1 3036/4885ALDH1A1 1718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.