SCHEMBL5458102

SCHEMBL5458102

Cc1c(N2CC(F)C(CNC(=O)OC(C)(C)C)C2)c(F)cc2c(=O)n(N)c(=O)n(C3CC3)c12

nearest known ligand 0.54

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SCN5A Q14524 1/20 0.35
KCNH2 Q12809 8/20 0.34
GFER P55789 1/20 0.33
EEF2K O00418 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14432200 1.00 SCN5A (0.35) SCN5AKCNH2GFEREEF2K
SCHEMBL4519617 0.93 KCNH2 (0.34) SCN5AKCNH2GFEREEF2K
SCHEMBL4519605 0.93 KCNH2 (0.34) SCN5AKCNH2GFEREEF2K
SCHEMBL4519609 0.93 KCNH2 (0.34) SCN5AKCNH2GFEREEF2K
SCHEMBL4501914 0.91 KCNH2 (0.37) KCNH2
SCHEMBL4515235 0.91 KCNH2 (0.37) KCNH2
SCHEMBL4501910 0.91 KCNH2 (0.37) KCNH2
SCHEMBL4515232 0.91 KCNH2 (0.37) KCNH2
SCHEMBL4501922 0.91 KCNH2 (0.37) KCNH2
SCHEMBL4513118 0.85 EEF2K (0.39) SCN5AKCNH2EEF2K

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070191333-A1 Antibacterial agents WARNER LAMBERT COMPANY LLC 2007-08-16 US disclosed
EP-1687296-A1 ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES Warner-Lambert Company LLC (US) 2006-08-09 EP disclosed
WO-2005049605-A1 ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES WARNER-LAMBERT COMPANY LLC (US) 2005-06-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070191333-A1 Antibacterial agents MRPL21, RPN2, FBL SCN5A 3616/4885KCNH2 2633/4885GFER 1342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.