RPN2

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

0 patent compounds predicted against RPN2, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Germline variants in RPN2 on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full RPN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to RPN2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision	PHASE3	COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Mobilization of Stem Cells With G-CSF for Collection From Patients With Diamond-Blackfan Anemia	PHASE2	COMPLETED
24-Week Study to Assess the PD, Safety, Tolerability, and PK of GLM101 in Participants With PMM2-CDG	PHASE2	COMPLETED
Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa	PHASE1	COMPLETED
MAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects (Wallaby)	PHASE1	COMPLETED
InsightRP2 Registry	nan	RECRUITING
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam	nan	UNKNOWN
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial	nan	COMPLETED
Biomarker for Hurler Disease (BioHurler)	nan	WITHDRAWN
The Natural History of Alpha-Mannosidosis	nan	COMPLETED
Protein Synthesis in the Brain of Patients With Fragile X Syndrome	nan	COMPLETED
Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome	nan	RECRUITING
CoMPaSS-NMD - Computational Models for New Patients Stratification Strategies of HNMD	nan	ENROLLING_BY_INVITATION
Gene Modifiers of Cystic Fibrosis Lung Disease	nan	ACTIVE_NOT_RECRUITING
Glycosylation in Patients With Galactosaemia	nan	COMPLETED
Using D-Galactose as a Food Supplement in Congenital Disorders of Glycosylation	nan	COMPLETED
Biomarker for Patients With Fabry Disease (BioFabry)	nan	WITHDRAWN
Effects of Subtenon-injected Autologous Platelet-rich Plasma on Visual Functions in Eyes With Retinitis Pigmentosa	nan	COMPLETED
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
Diagnosis of Primary Ciliary Dyskinesia	nan	COMPLETED
Investigations of Juvenile Neuronal Ceroid Lipofuscinosis	nan	RECRUITING
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia	nan	RECRUITING
Registry Gangliosidoses	nan	UNKNOWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a RPN2 binder may also engage these)

Protein	Name	Similarity
F1PCT7	—	1.000	F1PCT7 →
Q3SZI6	—	1.000	Q3SZI6 →
Q5RBM1	—	1.000	Q5RBM1 →
P25235	—	1.000	P25235 →
Q9DBG6	—	1.000	Q9DBG6 →
Q9GL01	—	0.994	Q9GL01 →
A0A0R4IVV0	—	0.983	A0A0R4IVV0 →
P53620	—	0.981	P53620 →
Q865F1	—	0.981	Q865F1 →
COPG1	Coatomer subunit gamma-1	0.980	landscape →
P55158	—	0.980	P55158 →
EMC1	ER membrane protein complex subunit 1	0.980	landscape →
P55156	—	0.980	P55156 →
Q9M2Q4	—	0.980	Q9M2Q4 →
Q08DK0	—	0.979	Q08DK0 →
A0AVI4	—	0.979	A0AVI4 →
Q0WW26	—	0.979	Q0WW26 →
Q6PD82	—	0.979	Q6PD82 →
Q6PGY6	—	0.979	Q6PGY6 →
Q93Z16	—	0.979	Q93Z16 →
Q9CRG1	—	0.979	Q9CRG1 →
A4R1D5	—	0.979	A4R1D5 →
Q14CX7	—	0.978	Q14CX7 →
C0NLX2	—	0.978	C0NLX2 →
A1L2I9	—	0.978	A1L2I9 →
Q0V3D6	—	0.978	Q0V3D6 →
Q5XHZ0	—	0.978	Q5XHZ0 →
Q7ZX96	—	0.977	Q7ZX96 →
Q7KNA0	—	0.977	Q7KNA0 →
Q8BWZ3	—	0.977	Q8BWZ3 →