SCHEMBL545827

SCHEMBL545827

NC(=O)C1=Cc2ccccc2OC1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.62
SMN1; SMN2 Q16637 6/20 0.55
NPC1 O15118 4/20 0.55
RAB9A P51151 4/20 0.55
MAPT P10636 3/20 0.55
NFKB1 P19838 3/20 0.55
NFKB2 Q00653 3/20 0.55
RELA Q04206 3/20 0.55
KMT2A Q03164 3/20 0.55
MEN1 O00255 2/20 0.55
CASP3 P42574 1/20 0.55
SENP8 Q96LD8 1/20 0.55
SENP7 Q9BQF6 1/20 0.55
SENP6 Q9GZR1 1/20 0.55
KDM4E B2RXH2 6/20 0.51
ALDH1A1 P00352 6/20 0.51
MAOB P27338 4/20 0.51
MAOA P21397 3/20 0.51
HPGD P15428 1/20 0.51
PKM P14618 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31560392 1.00 ALOX5 (0.62) ALOX5SMN1; SMN2NPC1RAB9AMAPT
Trifluoroacetic Acid SCHEMBL16669663 0.89 ALOX5 (0.52) ALOX5SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL4539281 0.86 ALOX5 (0.54) ALOX5SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL16397645 0.84 ALOX5 (0.64) ALOX5SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL212724 0.84 ALOX5 (0.64) ALOX5SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL919529 0.83 ALOX5 (0.48) ALOX5SMN1; SMN2NPC1RAB9AMAPT
Hydrochloric Acid SCHEMBL23532714 0.82 ALOX5 (0.62) ALOX5SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL9058393 0.82 ALOX5 (0.67) ALOX5SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL2154729 0.82 ALOX5 (0.62) ALOX5SMN1; SMN2NPC1RAB9AMAPT
Hydrochloric Acid SCHEMBL5770308 0.82 ALOX5 (0.62) ALOX5SMN1; SMN2NPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024222918-A1 BENZO SIX-MEMBERED HETEROCYCLIC GSPT1 PROTEIN DEGRADATION AGENT AND USE THEREOF 中国药科大学 2024-10-31 WO disclosed
EP-4267553-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2023-11-01 EP disclosed
EP-4180423-A1 NOVEL TNF ACTIVITY INHIBITOR COMPOUND, AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF ILAb Co., Ltd. (KR) 2023-05-17 EP disclosed
WO-2023070780-A1 MONOAMINE OXIDASE B INHIBITOR HAVING POTENTIAL IRON CHELATING ACTIVITY AND USE THEREOF 浙江工业大学 2023-05-04 WO disclosed
US-20230094176-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2023-03-30 US disclosed
CN-111346088-B Application of pyranochromene-3-formamide derivative Z20 in preparation of medicines for preventing and treating organ injury caused by sepsis 南方医科大学 2022-07-01 CN disclosed
WO-2022140520-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2022-06-30 WO disclosed
CN-113166123-A Novel insect repellent compounds 拜耳动物保健有限责任公司 2021-07-23 CN disclosed
EP-3837262-A1 N-CYANO-7-AZANORBORNANE DERIVATIVES AND USES THEREOF Amgen Inc. (US) 2021-06-23 EP disclosed
CN-112654628-A Selenophenochromic hydroxamic acid, preparation and application as angiogenesis inhibitor 拉脱维亚有机合成学院 2021-04-13 CN disclosed
WO-2012120262-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS LARSSON PIA (SE) 2012-09-13 WO disclosed
US-8110687-B2 Bicyclic compounds with kinase inhibitory activity MILLENNIUM PHARMACEUTICALS, INC. (US) 2012-02-07 US disclosed
US-20110263642-A1 METHODS FOR TREATMENT OF MULTIPLE SCLEROSIS FIBROGEN, INC. (US) 2011-10-27 US disclosed
EP-2341904-A1 METHODS FOR TREATMENT OF MULTIPLE SCLEROSIS Fibrogen, Inc. (US) 2011-07-13 EP disclosed
US-20100298580-A1 Process for the Preparation of 2H-Chromene-3-Carbamate Derivatives BIAL - PORTELA & CA, S.A. (PT) 2010-11-25 US disclosed
WO-2010024908-A1 METHODS FOR TREATMENT OF MULTIPLE SCLEROSIS FIBROGEN, INC. (US) 2010-03-04 WO disclosed
US-20070149533-A1 Bicyclic compounds with kinase inhibitory activity MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-06-28 US disclosed
US-20070060566-A1 Benzazepine derivatives as histamine h3 antagonists GLAXO GROUP LIMITED (GB) 2007-03-15 US disclosed
US-6414013-B1 KINASE INHIBITORS; ANTICANCER AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2002-07-02 US disclosed
WO-2001072735-A2 BENZOPYRANES USEFUL AS TNF ALPHA INHIBITORS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2001-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298580-A1 Process for the Preparation of 2H-Chromene-3-Carbamate Derivatives CYP8B1, CYP4B1, CYP3A4 ALOX5 3347/4885SMN1; SMN2 2508/4885NPC1 3028/4885
US-20110263642-A1 METHODS FOR TREATMENT OF MULTIPLE SCLEROSIS PMP22, MAG, NEFM ALOX5 239/4885SMN1; SMN2 97/4885NPC1 1125/4885
US-20070060566-A1 Benzazepine derivatives as histamine h3 antagonists HRH3, HRH4, HRH1 ALOX5 2396/4885SMN1; SMN2 2487/4885NPC1 2009/4885
US-20230094176-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC2, HDAC1 ALOX5 1060/4885SMN1; SMN2 3053/4885NPC1 2295/4885
US-20070149533-A1 Bicyclic compounds with kinase inhibitory activity MAP3K20, MAP3K1, MAP3K5 ALOX5 3821/4885SMN1; SMN2 3423/4885NPC1 1541/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.