Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 6/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 4/20 | 0.48 |
| ▸ | CASP7 | P55210 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982857 | 0.86 | F2 (0.60) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL31195705 | 0.82 | MAPT (0.65) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL11753126 | 0.79 | MAPT (0.54) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL395329 | 0.79 | MAPT (0.54) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL10099057 | 0.79 | MAPT (0.57) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL1004931 | 0.79 | MAPT (0.70) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL10745211 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL20780028 | 0.77 | MAPT (0.56) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL12927815 | 0.77 | MAPT (0.68) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL10745214 | 0.77 | KDM4E (0.43) | KDM4EALDH1A1MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0155610-B2 | PROCESS FOR THE MANUFACTURE OF 2-HYDROXY-(9H)-CARBAZOLE | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-01-08 | — | — | EP | claimed |
| EP-0233780-A2 | O-substituted oximino cephalosporins | ELI LILLY AND COMPANY (US) | 1987-08-26 | — | — | EP | claimed |
| EP-0155610-B1 | PROCESS FOR THE MANUFACTURE OF 2-HYDROXY-(9H)-CARBAZOLE | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | claimed |
| US-4628106-A | Process for the preparation of 2-hydroxy-(9H)-carbazole | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-12-09 | — | — | US | claimed |
| EP-0179217-A2 | Process for the preparation of 2-hydroxy-5,6,7,8-tetrahydrocarbazol and its salts, and their uses | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-04-30 | — | — | EP | claimed |
| EP-0155610-A1 | Process for the manufacture of 2-hydroxy-(9H)-carbazole | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-09-25 | — | — | EP | claimed |
| JP-61057555-A | — | — | None | — | — | JP | disclosed |
| US-20070197797-A1 | Compounds and methods for carbazole synthesis | ROCHE COLORADO CORPORATION | 2007-08-23 | — | — | US | disclosed |
| US-20070197797-A1 | Compounds and methods for carbazole synthesis | ROCHE COLORADO CORPORATION | 2007-08-23 | — | — | US | disclosed |
| US-20070197797-A1 | Compounds and methods for carbazole synthesis | ROCHE COLORADO CORPORATION | 2007-08-23 | — | — | US | disclosed |
| WO-2007077111-A1 | COMPOUNDS AND METHODS FOR CARBAZOLE SYNTHESIS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-12 | — | — | WO | disclosed |
| WO-2007077111-A1 | COMPOUNDS AND METHODS FOR CARBAZOLE SYNTHESIS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-12 | — | — | WO | disclosed |
| EP-1142883-A1 | NOVEL HETEROCYCLIC COMPOUNDS AND DRUG COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kabushiki Kaisha (JP) | 2001-10-10 | — | — | EP | disclosed |
| US-4628106-A | Process for the preparation of 2-hydroxy-(9H)-carbazole | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-12-09 | — | — | US | disclosed |
| EP-0179217-A2 | Process for the preparation of 2-hydroxy-5,6,7,8-tetrahydrocarbazol and its salts, and their uses | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0179217-A2 | Process for the preparation of 2-hydroxy-5,6,7,8-tetrahydrocarbazol and its salts, and their uses | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0179217-A2 | Process for the preparation of 2-hydroxy-5,6,7,8-tetrahydrocarbazol and its salts, and their uses | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-04-30 | — | — | EP | disclosed |
| JP-S6157555-A | MANUFACTURE OF 2-HYDROXY-5,6,7,8- TETRAHYDROCARBAZOLE, ALKALI- AND ALKALI EARTH SALTS OF 2-HYDROXY-5,6,7,8- TETRAHYDROCARBAZOLE AND USE | HOECHST AG | 1986-03-24 | — | — | JP | disclosed |
| EP-0155610-A1 | Process for the manufacture of 2-hydroxy-(9H)-carbazole | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-09-25 | — | — | EP | disclosed |
| EP-0155610-A1 | Process for the manufacture of 2-hydroxy-(9H)-carbazole | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-09-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197797-A1 | Compounds and methods for carbazole synthesis | CNR2, CNR1, CYP2J2 | KDM4E 2470/4885ALDH1A1 393/4885MAPT 4320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.