Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.56 |
| ▸ | MEN1 | O00255 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31195705 | 0.96 | MAPT (0.65) | F2MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5458644 | 0.86 | KDM4E (0.57) | F2MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2396914 | 0.79 | LMNA (0.64) | KDM4ELMNAPRKD1DRD2DRD1 | |
| SCHEMBL1465735 | 0.79 | F2 (0.60) | F2MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6826753 | 0.79 | MAPT (0.60) | F2MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1053506 | 0.79 | MAPT (0.93) | F2MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4778907 | 0.79 | MAPT (0.60) | F2MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2515756 | 0.79 | MAPT (0.60) | F2MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL30228634 | 0.78 | TAAR1 (0.59) | KMT2AKDM4ELMNAPRKD1DRD2 | |
| Hydrochloric Acid SCHEMBL5682360 | 0.78 | LMNA (0.62) | KDM4ELMNAPRKD1DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5001032-A | — | — | None | — | — | JP | disclosed |
| US-8486990-B2 | SirT inhibitors that bind to NAD | ELIXIR PHARMACEUTICALS, INC. (US) | 2013-07-16 | — | — | US | disclosed |
| EP-0839806-B1 | Substituted tricyclics | LILLY CO ELI (US) | 2003-07-09 | — | — | EP | disclosed |
| CN-1233176-A | Substituted tricyclics | LILLY CO ELI (US) | 1999-10-27 | — | — | CN | disclosed |
| WO-1998018464-A1 | SUBSTITUTED TRICYCLICS | ELI LILLY AND COMPANY (US) | 1998-05-07 | — | — | WO | disclosed |
| EP-0839806-A1 | Substituted tricyclics | ELI LILLY AND COMPANY (US) | 1998-05-06 | — | — | EP | disclosed |
| JP-H051032-A | CARBAZOL-6-OL DERIVATIVE AND ITS PRODUCTION | FUJI PHOTO FILM CO LTD | 1993-01-08 | — | — | JP | disclosed |