Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.58 |
| ▸ | NOS1 | P29475 | 6/20 | 0.54 |
| ▸ | FYN | P06241 | 5/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411134 | 0.85 | NOS1 (0.55) | PIK3CGNOS1PIK3CAPIK3CBHDAC6 | |
| SCHEMBL3766480 | 0.85 | NOS1 (0.55) | PIK3CGNOS1FYNPIK3CAPIK3CB | |
| SCHEMBL14983452 | 0.81 | PIK3CG (0.56) | PIK3CGFYNPIK3CAPIK3CBGAA | |
| SCHEMBL3765083 | 0.80 | NOS1 (0.72) | PIK3CGNOS1FYN | |
| SCHEMBL5481513 | 0.78 | NOS1 (0.65) | PIK3CGNOS1FYN | |
| SCHEMBL3760493 | 0.75 | PIK3CG (0.61) | PIK3CGNOS1PIK3CAPIK3CBHDAC6 | |
| SCHEMBL5523882 | 0.75 | NOS1 (0.74) | PIK3CGNOS1PIK3CAPIK3CBHDAC6 | |
| SCHEMBL4454283 | 0.74 | NOS1 (0.67) | PIK3CGNOS1PIK3CAMAPK1MAPK8 | |
| SCHEMBL4454688 | 0.73 | NOS1 (0.62) | PIK3CGNOS1PIK3CAPIK3CBHDAC6 | |
| SCHEMBL3762199 | 0.73 | NOS1 (0.57) | PIK3CGNOS1PIK3CAPIK3CBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032477-A1 | Pteridine derivatives useful for making pharmaceutical compositions | 4 AZA BIOSCIENCE NV (BE) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032477-A1 | Pteridine derivatives useful for making pharmaceutical compositions | TPMT, TYMS, TNF | PIK3CG 1315/4885NOS1 107/4885FYN 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.