⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021255 | 0.74 | — | — | |
| SCHEMBL14599879 | 0.72 | — | — | |
| SCHEMBL7163926 | 0.72 | — | — | |
| SCHEMBL14993152 | 0.72 | — | — | |
| SCHEMBL1076454 | 0.71 | — | — | |
| SCHEMBL3857558 | 0.71 | — | — | |
| SCHEMBL863910 | 0.69 | USP2 (0.40) | — | |
| SCHEMBL14119513 | 0.69 | — | — | |
| SCHEMBL6364418 | 0.69 | — | — | |
| SCHEMBL5692035 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476302-B2 | α-ketoamide derivatives useful endothelial lipase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-07-02 | — | — | US | disclosed |
| US-20120077847-A1 | ALPHA-KETOAMIDE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-03-29 | — | — | US | disclosed |
| US-8110593-B2 | Phenoxymethyl imidazoline derivatives and their use as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2012-02-07 | — | — | US | disclosed |
| US-20100120881-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| EP-2117310-A2 | CHEMICAL COMPOUNDS | Syngeta Participations AG (CH) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098657-A2 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2008-08-21 | — | — | WO | disclosed |
| EP-1160235-B1 | A method for producing alpha-hydroxycarboxylic acid | NIPPON CATALYTIC CHEM IND (JP) | 2006-09-20 | — | — | EP | disclosed |
| US-6864389-B2 | Method for producing α-hydroxycarboxylic acid | NIPPON SHOKUBAI CO., LTD. (JP) | 2005-03-08 | — | — | US | disclosed |
| US-20030171614-A1 | Method for producing alpha-hydroxycarboxylic acid | NIPPON SHOKUBAI CO., LTD. | 2003-09-11 | — | — | US | disclosed |
| EP-1160235-A2 | A method for producing alpha-hydroxycarboxylic acid | Nippon Shokubai Co., Ltd. (JP) | 2001-12-05 | — | — | EP | disclosed |
| US-5072021-A | Liquid crystals | MITSUI TOATSU CHEMICALS, INC. (JP) | 1991-12-10 | — | — | US | disclosed |