SCHEMBL5459149

SCHEMBL5459149

COC(=O)c1cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2cc(F)ccc2F)ccc1C

nearest known ligand 0.74

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 20/20 0.74
TBXA2R P21731 1/20 0.67
PTGER4 P35408 1/20 0.67
PTGER3 P43115 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5471423 0.94 PTGER1 (0.84) PTGER1TBXA2RPTGER4PTGER3
SCHEMBL5473683 0.92 PTGER1 (0.73) PTGER1TBXA2RPTGER4PTGER3
SCHEMBL5478190 0.91 PTGER1 (0.69) PTGER1TBXA2RPTGER4PTGER3
SCHEMBL5458801 0.91 PTGER1 (0.77) PTGER1TBXA2RPTGER4PTGER3
SCHEMBL5467708 0.91 PTGER1 (0.88) PTGER1TBXA2RPTGER4PTGER3
SCHEMBL5467943 0.88 PTGER1 (0.64) PTGER1TBXA2RPTGER4PTGER3
SCHEMBL5472050 0.88 PTGER1 (0.66) PTGER1TBXA2RPTGER4PTGER3
SCHEMBL5464582 0.87 PTGER1 (0.71) PTGER1TBXA2RPTGER4PTGER3
SCHEMBL5459102 0.87 PTGER1 (0.71) PTGER1TBXA2RPTGER4PTGER3
SCHEMBL5469531 0.87 PTGER1 (0.63) PTGER1TBXA2RPTGER4PTGER3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070072906-A1 Pyrrole compounds GLAXO GROUP LIMITED (GB) 2007-03-29 US disclosed
US-20070072906-A1 Pyrrole compounds GLAXO GROUP LIMITED (GB) 2007-03-29 US disclosed
US-20070072906-A1 Pyrrole compounds GLAXO GROUP LIMITED (GB) 2007-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070072906-A1 Pyrrole compounds PRMT9, EPOR, ADCYAP1R1 PTGER1 224/4885TBXA2R 251/4885PTGER4 596/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.