Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 17/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.53 |
| ▸ | PDE2A | O00408 | 2/20 | 0.53 |
| ▸ | PDE9A | O76083 | 2/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.53 |
| ▸ | PDE6C | P51160 | 2/20 | 0.53 |
| ▸ | PDE1A | P54750 | 2/20 | 0.53 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.53 |
| ▸ | PDE6D | O43924 | 1/20 | 0.53 |
| ▸ | PDE8A | O60658 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1263 | 0.90 | KMT2A (0.68) | KMT2AKDM4EPOLBPDE5APDE3B | |
| SCHEMBL5450370 | 0.90 | KMT2A (0.71) | KMT2AKDM4EPOLBPDE5APDE3B | |
| SCHEMBL5455423 | 0.85 | PDE5A (0.57) | KMT2AKDM4EPDE5APDE3BPDE3A | |
| SCHEMBL5455416 | 0.85 | PDE5A (0.57) | KMT2AKDM4EPDE5APDE3BPDE3A | |
| SCHEMBL5445750 | 0.84 | KMT2A (0.62) | KMT2AKDM4EPOLBPDE5APDE3B | |
| SCHEMBL6713800 | 0.83 | KMT2A (0.61) | KMT2AKDM4EPOLBPDE5APDE3B | |
| SCHEMBL5459779 | 0.82 | PDE5A (0.64) | KMT2AKDM4EPOLBPDE5APDE3B | |
| SCHEMBL1071 | 0.82 | KMT2A (0.83) | KMT2AKDM4EPOLBPDE5APDE3B | |
| SCHEMBL5458125 | 0.82 | KMT2A (0.59) | KMT2AKDM4EPOLBPDE5APDE3B | |
| SCHEMBL29655374 | 0.82 | KMT2A (0.83) | KMT2AKDM4EPOLBPDE5APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070219220-A1 | Pyrazolopyrimidinethione Derivatives, Salts and Solvates Thereof, Preparation Methods and Use Thereof | THE INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA (CN) | 2007-09-20 | — | — | US | disclosed |
| EP-1695976-A1 | PYRAZOLOPYRIMIDINETHIONE DERIVATIVES, SALTS AND SOLVATES THEREOF, PREPARATION METHODS AND USE THEREOF | Institute of Radiation Medicine Academy of Military Medical Sciences of the Pla (CN) | 2006-08-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219220-A1 | Pyrazolopyrimidinethione Derivatives, Salts and Solvates Thereof, Preparation Methods and Use Thereof | PDE5A, PDE3B, PDE3A | KMT2A 3164/4885KDM4E 2094/4885POLB 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.