Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139825 | 0.90 | HDAC1 (0.52) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL5458427 | 0.90 | HDAC6 (0.50) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL5462734 | 0.84 | HDAC6 (0.60) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL5461024 | 0.83 | PLA2G2A (0.51) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL5450617 | 0.83 | HDAC10 (0.51) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL5140664 | 0.79 | NR4A2 (0.52) | HTR6TP53PLA2G2APOLBMAPT | |
| SCHEMBL5457548 | 0.78 | CHRM1 (0.56) | HTR6TP53PLA2G2AMAPTMTNR1A | |
| SCHEMBL1608577 | 0.75 | HDAC6 (0.67) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL5139828 | 0.74 | HDAC3 (0.52) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL5131095 | 0.73 | PLA2G2A (0.52) | HTR6TP53PLA2G2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371281-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYCLICS LLC (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150299119-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS LLC | 2015-10-22 | — | — | US | disclosed |
| US-8900565-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYCLICS, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-20130156727-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-8338416-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYLICS, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20070281934-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299119-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC2 | HDAC6 10/4885HDAC1 2/4885HDAC2 3/4885 |
| US-20070281934-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC2 | HDAC6 10/4885HDAC1 2/4885HDAC2 3/4885 |
| US-20130156727-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC2 | HDAC6 10/4885HDAC1 2/4885HDAC2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.