Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253172 | 0.92 | HTT (0.48) | PKMHCRTR2HCRTR1MAPTSMN1; SMN2 | |
| SCHEMBL3253166 | 0.92 | HTT (0.48) | PKMHCRTR2HCRTR1MAPTSMN1; SMN2 | |
| SCHEMBL8272210 | 0.89 | PKM (0.45) | PKMHCRTR2HCRTR1MAPTSMN1; SMN2 | |
| SCHEMBL4871558 | 0.88 | PKM (0.46) | PKMHCRTR2HCRTR1MAPTSMN1; SMN2 | |
| SCHEMBL3249066 | 0.88 | PKM (0.46) | PKMHCRTR2HCRTR1MAPTSMN1; SMN2 | |
| SCHEMBL3250138 | 0.88 | PSEN1 (0.50) | PKMHCRTR2HCRTR1 | |
| SCHEMBL3249207 | 0.87 | PKM (0.46) | PKMHCRTR2HCRTR1MAPTSMN1; SMN2 | |
| SCHEMBL3256226 | 0.87 | PKM (0.44) | PKMHCRTR2HCRTR1MAPTSMN1; SMN2 | |
| SCHEMBL3251909 | 0.85 | HCRTR2 (0.44) | PKMHCRTR2HCRTR1MAPTSMN1; SMN2 | |
| SCHEMBL3247826 | 0.85 | PKM (0.41) | PKMHCRTR2HCRTR1MAPTMCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185136-A1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185136-A1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | HCRTR2, GIPR, SSTR2 | PKM 2524/4885HCRTR2 1/4885HCRTR1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.