SCHEMBL546069

SCHEMBL546069

O=C1[N]C=CC(=S)N1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL536791 0.65
SCHEMBL3077092 0.63
SCHEMBL711736 0.61
SCHEMBL703169 0.61
SCHEMBL292626 0.56
SCHEMBL432911 0.54
Hydrochloric Acid SCHEMBL3861041 0.54
SCHEMBL5602042 0.53
SCHEMBL2041573 0.53
SCHEMBL2042013 0.53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 192 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3284832-B1 APTAMER WITH IMPROVED RATE OF DISSOCIATION, AND NON-COVALENT APTAMER-TARGET COMPLEX THEREOF SOMALOGIC OPERATING CO INC (US) 2023-06-07 EP claimed
EP-3284832-A2 METHOD FOR GENERATING APTAMERS WITH IMPROVED OFF-RATES Somalogic, Inc. (US) 2018-02-21 EP claimed
EP-2933340-B1 Aptamers with uridines and/or thymidines substituted at the 5-position with a benzyl group SOMALOGIC INC (US) 2017-09-06 EP claimed
US-20170137819-A1 Method for Generating Aptamers with Improved Off-Rates SOMALOGIC, INC. 2017-05-18 US claimed
EP-2933340-A1 Chemically modified aptamers with improved off-rates Somalogic, Inc. (US) 2015-10-21 EP claimed
US-20150197753-A1 Method for Generating Aptamers with Improved Off-Rates SOMALOGIC, INC. 2015-07-16 US claimed
US-8975388-B2 Method for generating aptamers with improved off-rates SOMALOGIC, INC. (US) 2015-03-10 US claimed
US-8404830-B2 Method for generating aptamers with improved off-rates SOMALOGIC, INC. (US) 2013-03-26 US claimed
US-20070179100-A1 Protected monomers ALNYLAM PHARMACEUTICALS, INC. 2007-08-02 US claimed
EP-1625138-A2 PROTECTED MONOMERS Alnylam Pharmaceuticals Inc. (US) 2006-02-15 EP claimed
US-6300483-B1 FORM, IN COMBINATION WITH AN RNA SUBSTRATE, A STRUCTURE RESEMBLING A HAMMERHEAD STRUCTURE; ANTISENSE THERAPY RIBOZYME PHARMACEUTICALS, INC. 2001-10-09 US claimed
EP-1019497-A1 HAMMERHEAD RIBOZYMES WITH EXTENDED CLEAVAGE RULE RIBOZYME PHARMACEUTICALS, INC. (US) 2000-07-19 EP claimed
JP-2000501284-A 2000-02-08 JP claimed
WO-1998058057-A9 COMPOSITIONS INDUCING CLEAVAGE OF RNA MOTIFS INNOVIR LAB INC (US) 1999-04-08 WO claimed
WO-1998058057-A1 COMPOSITIONS INDUCING CLEAVAGE OF RNA MOTIFS INNOVIR LABORATORIES, INC. (US) 1998-12-23 WO claimed
WO-1998058058-A1 HAMMERHEAD RIBOZYMES WITH EXTENDED CLEAVAGE RULE RIBOZYME PHARMACEUTICALS, INC. (US) 1998-12-23 WO claimed
EP-0866865-A1 CHIMERIC OLIGOMERS HAVING AN RNA-CLEAVAGE ACTIVITY Vimrx Holdings, Ltd. (US) 1998-09-30 EP claimed
WO-1997018312-A9 CHIMERIC OLIGOMERS HAVING AN RNA-CLEAVAGE ACTIVITY 1998-08-13 WO claimed
WO-1997018312-A1 CHIMERIC OLIGOMERS HAVING AN RNA-CLEAVAGE ACTIVITY VIMRX HOLDINGS, LTD. (US) 1997-05-22 WO claimed
US-3935184-A Synthetic polyoxin type nucleosides SYNTEX (U.S.A.) INC. (US) 1976-01-27 US claimed