Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.62 |
| ▸ | RAF1 | P04049 | 14/20 | 0.62 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544903 | 0.88 | BRAF (0.73) | BRAFRAF1KDRKCNH2 | |
| SCHEMBL5424238 | 0.88 | BRAF (0.61) | BRAFRAF1KDR | |
| SCHEMBL545889 | 0.87 | BRAF (0.63) | BRAFRAF1KDRABL1EGFR | |
| SCHEMBL10200873 | 0.87 | BRAF (0.60) | BRAFRAF1KDR | |
| SCHEMBL546174 | 0.86 | RAF1 (0.62) | BRAFRAF1 | |
| SCHEMBL545326 | 0.86 | BRAF (0.83) | BRAFRAF1KDR | |
| SCHEMBL546037 | 0.86 | BRAF (0.69) | BRAFRAF1KDRABL1EGFR | |
| SCHEMBL546169 | 0.86 | BRAF (0.68) | BRAFRAF1KDRABL1EGFR | |
| SCHEMBL546087 | 0.85 | BRAF (0.68) | BRAFRAF1KDRABL1EGFR | |
| SCHEMBL545560 | 0.85 | BRAF (0.68) | BRAFRAF1KDRABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |