Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | KIT | P10721 | 6/20 | 0.47 |
| ▸ | FLT3 | P36888 | 6/20 | 0.47 |
| ▸ | AURKA | O14965 | 4/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.47 |
| ▸ | CSF1R | P07333 | 4/20 | 0.47 |
| ▸ | FLT1 | P17948 | 4/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.47 |
| ▸ | FLT4 | P35916 | 4/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.47 |
| ▸ | PLK4 | O00444 | 3/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.47 |
| ▸ | LYN | P07948 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.47 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464363 | 0.86 | KDR (0.49) | KDRKITFLT3AURKAROCK2 | |
| SCHEMBL1463312 | 0.86 | KDR (0.48) | KDRKITFLT3AURKAROCK2 | |
| SCHEMBL5476680 | 0.86 | KDR (0.46) | KDRKITFLT3AURKAROCK2 | |
| SCHEMBL5468764 | 0.85 | CYP3A4 (0.39) | KDRKITFLT3ROCK1AURKB | |
| SCHEMBL5471398 | 0.83 | TACR1 (0.43) | KDRKITFLT3AURKACSF1R | |
| SCHEMBL5474061 | 0.75 | KDR (0.50) | KDRKITFLT3AURKAROCK2 | |
| SCHEMBL1463540 | 0.75 | GRIK1 (0.50) | KDRKITFLT3AURKAROCK2 | |
| SCHEMBL5471433 | 0.74 | KDR (0.52) | KDRKITFLT3AURKAROCK2 | |
| SCHEMBL5950680 | 0.73 | GRIK1 (0.68) | GRIK1HTTMAPTKDM4EMEN1 | |
| SCHEMBL5950633 | 0.73 | TRPV1 (0.37) | KDRKITFLT3CSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | NEUROSEARCH A/S (DK) | 2007-12-20 | — | — | US | claimed |
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | NEUROSEARCH A/S (DK) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | KCNJ2, KCNH2, KCNH3 | KDR 1142/4885KIT 1089/4885FLT3 2643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.